132378 20240311111224.0 doi 10.1109/TBME.2019.2928645 sideral 117864 ART-2020-117864 eng Garcia-Sanchez, T. Successful Tumor Electrochemotherapy Using Sine Waves 2020 Objective: The purpose of this work is to assess the ability of sine waves to perform electrochemotherapy (ECT) and to study the dependence of the frequency of the applied sine wave on the treatment efficacy. Methods: A subcutaneous tumor model in mice was used, and the electric field was delivered in combination with bleomycin. Sinusoidal electric fields of different frequencies, amplitudes, and durations were compared to square waves. Computer simulations were additionally performed. Results: The results confirmed the ability of a sinusoidal electric field to obtain successful ECT responses. A strong dependence on frequency was obtained. The efficacy of the treatment decreased when the frequency of the sine waves was increased. At low sinusoidal frequency, the efficacy of the treatment is very similar to that obtained with a square wave. The collateral effects such as skin burns and muscle contractions decreased for the highest frequency assayed. Conclusion: The use of sine wave burst represents a feasible option for the treatment of cancer by ECT. Significance: These results could have important implications for the treatment of cancer in the clinical world where ECT is performed with dc square pulses. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.538 2020 ENGINEERING, BIOMEDICAL 24 / 89 = 0.27 2020 Q2 T1 1.147 2020 Biomedical Engineering 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Mercadal, B. Polrot, M. Muscat, A. Sarnago, H. Universidad de Zaragoza (orcid)0000-0001-8399-4650 Lucia, O. Universidad de Zaragoza (orcid)0000-0002-1284-9007 Mir, L.M. 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 67, 4 (2020), 1040-1049 IEEE trans. biomed. eng. IEEE Transactions on Biomedical Engineering 0018-9294 738974 http://zaguan.unizar.es/record/132378/files/texto_completo.pdf Postprint 3359052 http://zaguan.unizar.es/record/132378/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:132378 articulos driver 2024-03-11-09:48:57 ARTICLE