000132388 001__ 132388
000132388 005__ 20240319081011.0
000132388 0247_ $$2doi$$a10.3390/diagnostics12071705
000132388 0248_ $$2sideral$$a130350
000132388 037__ $$aART-2022-130350
000132388 041__ $$aeng
000132388 100__ $$aFeito, Jorge
000132388 245__ $$aPacinian corpuscles as a diagnostic clue of ledderhose disease-A case report and mapping of Pacinian corpuscles of the sole
000132388 260__ $$c2022
000132388 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132388 5203_ $$aBackground: Plantar fibromatosis, known as Ledderhose disease, is a neoplastic disease characterized by a locally-aggressive bland fibroblastic proliferation. Although Pacinian corpuscles alterations are commonly described in palmar fibromatosis, there are still no references about Pacinian corpuscles alterations in the rarer plantar version. Methods: We present a case report where a wide cutaneous resection, including the plantar fascia was performed, allowing a detailed study of Pacinian corpuscles. Pacinian corpuscles were analyzed using immunohistochemistry for neurofilament proteins, S100 protein, CD34, vimentin, glucose transporter 1, epithelial membrane antigen, neural-cell adhesion molecule, actin, desmin, type IV collagen, and high-affinity neurotrophin Trk-receptors. Moreover, the density and the size of the corpuscles were determined. Results: A clear increase in the number (hyperplasia) of Pacinian corpuscles was evidenced in the Ledderhose disease plantar fascia in comparison with similarly aged normal subjects. Pacinian hypertrophy was not demonstrated, but a significant decrease in the number of corpuscular lamellae was noted, with a subsequent increase in the interlamellar spaces. Pacinian corpuscles from the pathological plantar fascia showed an abnormal structure and immunohistochemical profile, generally without identifiable axons, and also absence of an inner core or an intermediate layer. Moreover, other molecules related with trophic maintenance of corpuscles were also absent. Finally, a vascular proliferation was commonly noted in some corpuscles, which involved all corpuscular constituents. Conclusion: The observed Pacinian corpuscles hyperplasia could be considered a diagnostic clue of plantar fibromatosis.
000132388 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132388 590__ $$a3.6$$b2022
000132388 591__ $$aMEDICINE, GENERAL & INTERNAL$$b64 / 169 = 0.379$$c2022$$dQ2$$eT2
000132388 592__ $$a0.67$$b2022
000132388 593__ $$aClinical Biochemistry$$c2022$$dQ2
000132388 594__ $$a3.6$$b2022
000132388 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132388 700__ $$0(orcid)0000-0003-1206-4514$$aEsteban, Ruth$$uUniversidad de Zaragoza
000132388 700__ $$aGarcía-Martínez, María Lourdes
000132388 700__ $$aGarcía-Alonso, Francisco J.
000132388 700__ $$aRodríguez-Martín, Raquel
000132388 700__ $$aBelen Rivas-Marcos, María
000132388 700__ $$aCobo, Juan L.
000132388 700__ $$aMartín-Biedma, Benjamin
000132388 700__ $$0(orcid)0000-0002-0595-719X$$aLahoz, Manuel$$uUniversidad de Zaragoza
000132388 700__ $$aVega, Jose A.
000132388 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000132388 773__ $$g12, 7 (2022), 1705 [11 pp.]$$tDiagnostics$$x2075-4418
000132388 8564_ $$s5788384$$uhttps://zaguan.unizar.es/record/132388/files/texto_completo.pdf$$yVersión publicada
000132388 8564_ $$s2587637$$uhttps://zaguan.unizar.es/record/132388/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132388 909CO $$ooai:zaguan.unizar.es:132388$$particulos$$pdriver
000132388 951__ $$a2024-03-18-15:09:27
000132388 980__ $$aARTICLE