000132389 001__ 132389
000132389 005__ 20241125101155.0
000132389 0247_ $$2doi$$a10.1109/TPEL.2022.3212783
000132389 0248_ $$2sideral$$a130200
000132389 037__ $$aART-2023-130200
000132389 041__ $$aeng
000132389 100__ $$0(orcid)0000-0003-2848-170X$$aLópez Alonso, Borja$$uUniversidad de Zaragoza
000132389 245__ $$aMultiple output inverter and monitoring system for homogeneous electroporation
000132389 260__ $$c2023
000132389 5203_ $$aElectroporation is a phenomenon that increases the permeability of cells by applying an electric field. This technique has relevant applications to cancer treatment using both electrochemotherapy and tumor ablation using irreversible electroporation. In order to carry out these treatments, new power converters are needed to apply of output voltages of several kV and output currents of tens of A in pulses of a width of µs. In addition, to achieve safe and relapse-free treatments, it is necessary to generate a controlled and uniform electric field. A challenge in current treatments is to ensure effective treatments despite tissue heterogeneity. In this context, this paper proposes a new pulse generator that allows the use of a multi-electrode structure that enables the application of a uniform electric field in multiple directions to avoid issues related to tissue heterogeneity. The proposed generator also allows the continuous monitoring of the treatment to adequately control the generator and apply a safer and more effective treatment. An 18-output 1500-V experimental prototype was designed, implemented, and tested using vegetal tissue, proving the feasibility of this proposal.
000132389 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000132389 590__ $$a6.6$$b2023
000132389 592__ $$a3.644$$b2023
000132389 591__ $$aENGINEERING, ELECTRICAL & ELECTRONIC$$b39 / 353 = 0.11$$c2023$$dQ1$$eT1
000132389 593__ $$aElectrical and Electronic Engineering$$c2023$$dQ1
000132389 594__ $$a15.2$$b2023
000132389 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000132389 700__ $$0(orcid)0000-0002-1284-9007$$aSarnago Andía, Héctor$$uUniversidad de Zaragoza
000132389 700__ $$0(orcid)0000-0002-9655-5531$$aBurdío Pinilla, José Miguel$$uUniversidad de Zaragoza
000132389 700__ $$0(orcid)0000-0001-8399-4650$$aLucía Gil, Oscar$$uUniversidad de Zaragoza
000132389 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000132389 773__ $$g38, 2 (2023), 1935-1947$$pIEEE trans. power electron.$$tIEEE Transactions on Power Electronics$$x0885-8993
000132389 8564_ $$s1146259$$uhttps://zaguan.unizar.es/record/132389/files/texto_completo.pdf$$yPostprint
000132389 8564_ $$s3499593$$uhttps://zaguan.unizar.es/record/132389/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000132389 909CO $$ooai:zaguan.unizar.es:132389$$particulos$$pdriver
000132389 951__ $$a2024-11-22-12:08:44
000132389 980__ $$aARTICLE