000132390 001__ 132390 000132390 005__ 20241125101142.0 000132390 0247_ $$2doi$$a10.1016/j.jpain.2023.07.021 000132390 0248_ $$2sideral$$a137469 000132390 037__ $$aART-2023-137469 000132390 041__ $$aeng 000132390 100__ $$aBellosta-López, Pablo 000132390 245__ $$aLongitudinal Changes and Associations Between Quantitative Sensory Testing and Psychological Factors in Whiplash-Associated Disorders: A Systematic Review and Meta-Analyses-Based Data Synthesis 000132390 260__ $$c2023 000132390 5060_ $$aAccess copy available to the general public$$fUnrestricted 000132390 5203_ $$aWhiplash-associated disorders (WAD) represent a multifactorial condition often accompanied by altered nociceptive processing and psychological factors. This systematic review on acute and chronic WAD aimed to investigate the relationship between quantitative sensory testing (QST) and psychological factors and quantify whether their trajectories over time follow a similar pattern to disability levels. Eight databases were searched until October 2022. When 2 prospective studies examined the same QST or psychological variable, data synthesis was performed with random-effects meta-analysis by pooling within-group standardized mean differences from baseline to 3-, 6-, and 12-month follow-ups. From 5,754 studies, 49 comprising 3,825 WAD participants were eligible for the review and 14 for the data synthesis. Altered nociceptive processing in acute and chronic WAD, alongside worse scores on psychological factors, were identified. However, correlations between QST and psychological factors were heterogeneous and inconsistent. Furthermore, disability levels, some QST measures, and psychological factors followed general positive improvement over time, although there were differences in magnitude and temporal changes. These results may indicate that altered psychological factors and increased local pain sensitivity could play an important role in both acute and chronic WAD, although this does not exclude the potential influence of factors not explored in this review. 000132390 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/FPI/CPB09-2018$$9info:eu-repo/grantAgreement/ES/MCIU/EST21-00453$$9info:eu-repo/grantAgreement/ES/MCIU/FPU19-05237 000132390 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000132390 590__ $$a4.0$$b2023 000132390 592__ $$a1.339$$b2023 000132390 591__ $$aCLINICAL NEUROLOGY$$b51 / 280 = 0.182$$c2023$$dQ1$$eT1 000132390 593__ $$aAnesthesiology and Pain Medicine$$c2023$$dQ1 000132390 591__ $$aNEUROSCIENCES$$b86 / 310 = 0.277$$c2023$$dQ2$$eT1 000132390 593__ $$aNeurology (clinical)$$c2023$$dQ1 000132390 593__ $$aNeurology$$c2023$$dQ1 000132390 594__ $$a6.3$$b2023 000132390 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000132390 700__ $$aDoménech-García, Víctor 000132390 700__ $$aOrtiz-Lucas, María 000132390 700__ $$aLluch-Girbés, Enrique 000132390 700__ $$0(orcid)0000-0002-9201-0120$$aHerrero, Pablo$$uUniversidad de Zaragoza 000132390 700__ $$aSterling, Michele 000132390 700__ $$aChristensen, Steffan W.M. 000132390 7102_ $$11006$$2413$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Fisioterapia 000132390 773__ $$g25, 1 (2023), 12-30$$pJ. pain$$tJOURNAL OF PAIN$$x1526-5900 000132390 8564_ $$s6984061$$uhttps://zaguan.unizar.es/record/132390/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/semantics/openAccess 000132390 8564_ $$s1560277$$uhttps://zaguan.unizar.es/record/132390/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/semantics/openAccess 000132390 909CO $$ooai:zaguan.unizar.es:132390$$particulos$$pdriver 000132390 951__ $$a2024-11-22-12:02:51 000132390 980__ $$aARTICLE