000132417 001__ 132417
000132417 005__ 20240319081030.0
000132417 0247_ $$2doi$$a10.3390/medicina58020178
000132417 0248_ $$2sideral$$a137591
000132417 037__ $$aART-2022-137591
000132417 041__ $$aeng
000132417 100__ $$0(orcid)0000-0002-5869-4450$$aPascual-Mancho, Jara$$uUniversidad de Zaragoza
000132417 245__ $$aBrain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
000132417 260__ $$c2022
000132417 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132417 5203_ $$aBackground and Objectives: Fetal growth restriction (FGR) is a severe obstetric disease characterized by a low fetal size entailing a set of undesired consequences. For instance, previous studies have noticed a worrisome association between FGR with an abnormal neurodevelopment. However, the precise link between FGR and neurodevelopmental alterations are not yet fully understood yet. Brain-derived neurotrophic factor (BDNF) is a critical neurotrophin strongly implicated in neurodevelopmental and other neurological processes. In addition, serum levels of BDNF appears to be an interesting indicator of pathological pregnancies, being correlated with the neonatal brain levels. Therefore, the aim of this study is to analyze the blood levels of BDNF in the cord blood from fetuses with FGR in comparison to those with weight appropriate for gestational age (AGA). Materials and Methods: In this study, 130 subjects were recruited: 91 in group A (AGA fetuses); 39 in group B (16 FGR fetuses with exclusively middle cerebral artery (MCA) pulsatility index (PI) < 5th percentile and 23 with umbilical artery (UA) PI > 95th percentile). Serum levels of BDNF were determined through ELISA reactions in these groups. Results: Our results show a significant decrease in cord blood levels of BDNF in FGR and more prominently in those with UA PI >95th percentile in comparison to AGA. FGR fetuses with exclusively decreased MCA PI below the 5th percentile also show reduced levels of BDNF than AGA, although this difference was not statistically significant. Conclusions: Overall, our study reports a potential pathophysiological link between reduced levels of BDNF and neurodevelopmental alterations in fetuses with FGR. However, further studies should be conducted in those FGR subjects with MCA PI < 5th percentile in order to understand the possible implications of BDNF in this group.
000132417 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI18-00912
000132417 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132417 590__ $$a2.6$$b2022
000132417 591__ $$aMEDICINE, GENERAL & INTERNAL$$b89 / 169 = 0.527$$c2022$$dQ3$$eT2
000132417 592__ $$a0.59$$b2022
000132417 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2
000132417 594__ $$a3.6$$b2022
000132417 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132417 700__ $$aPintado-Recarte, Pilar
000132417 700__ $$aMorales-Camino, Jorge C.
000132417 700__ $$aRomero-Román, Carlos
000132417 700__ $$aHernández-Martin, Concepción
000132417 700__ $$aBravo, Coral
000132417 700__ $$aBujan, Julia
000132417 700__ $$aAlvarez-Mon, Melchor
000132417 700__ $$aOrtega, Miguel A.
000132417 700__ $$aDe León-Luis, Juan
000132417 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000132417 773__ $$g58, 2 (2022), 178 [10 pp.]$$pMedicina-LithuaniaMedicina (Kaunas)$$tMedicina (Lithuania)$$x1010-660X
000132417 8564_ $$s791782$$uhttps://zaguan.unizar.es/record/132417/files/texto_completo.pdf$$yVersión publicada
000132417 8564_ $$s2851600$$uhttps://zaguan.unizar.es/record/132417/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132417 909CO $$ooai:zaguan.unizar.es:132417$$particulos$$pdriver
000132417 951__ $$a2024-03-18-17:07:12
000132417 980__ $$aARTICLE