000132431 001__ 132431
000132431 005__ 20240705134157.0
000132431 0247_ $$2doi$$a10.1021/acs.nanolett.3c04466
000132431 0248_ $$2sideral$$a137630
000132431 037__ $$aART-2024-137630
000132431 041__ $$aeng
000132431 100__ $$aDeng, Linlin
000132431 245__ $$aEnhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for <i>in Vitro</i> Prodrug Activation by Modulating the Polymer’s Microstructure
000132431 260__ $$c2024
000132431 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132431 5203_ $$aBioorthogonal catalysis employing transition metal catalysts is a promising strategy for the in situ synthesis of imaging and therapeutic agents in biological environments. The transition metal Pd has been widely used as a bioorthogonal catalyst, but bare Pd poses challenges in water solubility and catalyst stability in cellular environments. In this work, Pd(0) loaded amphiphilic polymeric nanoparticles are applied to shield Pd in the presence of living cells for the in situ generation of a fluorescent dye and anticancer drugs. Pd(0) loaded polymeric nanoparticles prepared by the reduction of the corresponding Pd(II)-polymeric nanoparticles are highly active in the deprotection of pro-rhodamine dye and anticancer prodrugs, giving significant fluorescence enhancement and toxigenic effects, respectively, in HepG2 cells. In addition, we show that the microstructure of the polymeric nanoparticles for scaffolding Pd plays a critical role in tuning the catalytic efficiency, with the use of the ligand triphenylphosphine as a key factor for improving the catalyst stability in biological environments.
000132431 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127847OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PDC2022-133866-I00
000132431 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132431 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132431 700__ $$aSathyan, Anjana
000132431 700__ $$aAdam, Catherine
000132431 700__ $$aUnciti-Broceta, Asier
000132431 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Víctor$$uUniversidad de Zaragoza
000132431 700__ $$aPalmans, Anja R. A.
000132431 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000132431 773__ $$g24, 7 (2024), 2242-2249$$pNano lett.$$tNano Letters$$x1530-6984
000132431 8564_ $$s4590516$$uhttps://zaguan.unizar.es/record/132431/files/texto_completo.pdf$$yVersión publicada
000132431 8564_ $$s3134795$$uhttps://zaguan.unizar.es/record/132431/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132431 909CO $$ooai:zaguan.unizar.es:132431$$particulos$$pdriver
000132431 951__ $$a2024-07-05-12:50:05
000132431 980__ $$aARTICLE