132438 20260217205504.0 doi 10.3389/fimmu.2024.1289303 sideral 137568 ART-2024-137568 eng Morte-Romea, Elena Universidad de Zaragoza (orcid)0000-0001-9262-2461 CAR immunotherapy for the treatment of infectious diseases: a systematic review 2024 Access copy available to the general public Unrestricted Immunotherapy treatments aim to modulate the host’s immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer. Among different immunotherapies reaching clinical application during the last years, chimeric antigen receptor (CAR) immunotherapy has emerged as an effective treatment for cancer where different CAR T cells have already been approved. Yet their use against infectious diseases is an area still relatively poorly explored, albeit with tremendous potential for research and clinical application. Infectious diseases represent a global health challenge, with the escalating threat of antimicrobial resistance underscoring the need for alternative therapeutic approaches. This review aims to systematically evaluate the current applications of CAR immunotherapy in infectious diseases and discuss its potential for future applications. Notably, CAR cell therapies, initially developed for cancer treatment, are gaining recognition as potential remedies for infectious diseases. The review sheds light on significant progress in CAR T cell therapy directed at viral and opportunistic fungal infections. info:eu-repo/grantAgreement/ES/AEI/PID2020-113963RB-I00 info:eu-repo/grantAgreement/ES/AEI/RYC2022-036627-I info:eu-repo/grantAgreement/ES/DGA/B29-23R info:eu-repo/grantAgreement/ES/DGA/LMP39_21 info:eu-repo/grantAgreement/ES/ISCIII/CB21-13-00087 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.9 2024 IMMUNOLOGY 34 / 183 = 0.186 2024 Q1 T1 1.941 2024 Immunology and Allergy 2024 Q1 Immunology 2024 Q1 10.8 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pesini, Cecilia Pellejero-Sagastizábal, Galadriel Universidad de Zaragoza Letona-Giménez, Santiago Martínez-Lostao, Luis Universidad de Zaragoza (orcid)0000-0003-3043-147X Loscos Aranda, Silvia Toyas, Carla (orcid)0000-0002-4217-6317 Redrado, Sergio Dolader-Ballesteros, Elena Universidad de Zaragoza Arias, Maykel Galvez, Eva M. Sanz-Pamplona, Rebeca Pardo, Julián Universidad de Zaragoza (orcid)0000-0003-0154-0730 Paño-Pardo, Jose Ramón Universidad de Zaragoza (orcid)0000-0002-9600-8116 Ramírez-Labrada, Ariel (orcid)0000-0002-3888-7036 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 15 (2024), 1289303 [13 pp.] Front. immunol. Frontiers in Immunology 1664-3224 2887353 http://zaguan.unizar.es/record/132438/files/texto_completo.pdf Versión publicada 2153197 http://zaguan.unizar.es/record/132438/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132438 articulos driver 2026-02-17-20:22:49 ARTICLE