000132798 001__ 132798
000132798 005__ 20240315113107.0
000132798 0247_ $$2doi$$a10.1186/s13567-024-01267-0
000132798 0248_ $$2sideral$$a137682
000132798 037__ $$aART-2024-137682
000132798 041__ $$aeng
000132798 100__ $$0(orcid)0000-0002-2126-2232$$aUruén, Cristina$$uUniversidad de Zaragoza
000132798 245__ $$aGenomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits
000132798 260__ $$c2024
000132798 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132798 5203_ $$aStreptococcus suis is a zoonotic pathogen that causes a major health problem in the pig production industry worldwide. Spain is one of the largest pig producers in the world. This work aimed to investigate the genetic and phenotypic features of invasive S. suis isolates recovered in Spain. A panel of 156 clinical isolates recovered from 13 Autonomous Communities, representing the major pig producers, were analysed. MLST and serotyping analysis revealed that most isolates (61.6%) were assigned to ST1 (26.3%), ST123 (18.6%), ST29 (9.6%), and ST3 (7.1%). Interestingly, 34 new STs were identified, indicating the emergence of novel genetic lineages. Serotypes 9 (27.6%) and 1 (21.8%) prevailed, followed by serotypes 7 (12.8%) and 2 (12.2%). Analysis of 13 virulence-associated genes showed significant associations between ST, serotype, virulence patterns, and clinical features, evidencing particular virulence traits associated with genetic clusters. The pangenome was generated, and the core genome was distributed in 7 Bayesian groups where each group included a variable set of over- and under-represented genes of different categories. The study provides comprehensive data and knowledge to improve the design of new vaccines, antimicrobial treatments, and bacterial typing approaches.
000132798 536__ $$9info:eu-repo/grantAgreement/ES/DGA/LMP58-21$$9info:eu-repo/grantAgreement/ES/MICINN AEI PID2020-114617RB-100AEI-10.13039-501100011033$$9info:eu-repo/grantAgreement/ES/UZ/UZ2020-BIO-01
000132798 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000132798 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132798 700__ $$aFernandez, Ana
000132798 700__ $$aArnal, José Luis
000132798 700__ $$adel Pozo, Mateo
000132798 700__ $$aAmoribieta, Maria Casas
000132798 700__ $$0(orcid)0000-0002-1204-4356$$ade Blas, Ignacio$$uUniversidad de Zaragoza
000132798 700__ $$aJurado, Paula
000132798 700__ $$0(orcid)0000-0001-9513-0219$$aCalvo, Jorge Hugo
000132798 700__ $$aGottschalk, Marcelo
000132798 700__ $$aGonzález-Vázquez, Luis Daniel
000132798 700__ $$aArenas, Miguel
000132798 700__ $$0(orcid)0000-0002-1974-9025$$aMarín, Clara M.
000132798 700__ $$0(orcid)0000-0002-8134-0693$$aArenas, Jesús$$uUniversidad de Zaragoza
000132798 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000132798 773__ $$g55, 1 (2024), [16 pp.]$$pVet. res.$$tVeterinary Research$$x0928-4249
000132798 8564_ $$s4649221$$uhttps://zaguan.unizar.es/record/132798/files/texto_completo.pdf$$yVersión publicada
000132798 8564_ $$s2207719$$uhttps://zaguan.unizar.es/record/132798/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132798 909CO $$ooai:zaguan.unizar.es:132798$$particulos$$pdriver
000132798 951__ $$a2024-03-15-08:49:56
000132798 980__ $$aARTICLE