132798 20260217205456.0 doi 10.1186/s13567-024-01267-0 sideral 137682 ART-2024-137682 eng Uruén, Cristina Universidad de Zaragoza (orcid)0000-0002-2126-2232 Genomic and phenotypic analysis of invasive Streptococcus suis isolated in Spain reveals genetic diversification and associated virulence traits 2024 Access copy available to the general public Unrestricted Streptococcus suis is a zoonotic pathogen that causes a major health problem in the pig production industry worldwide. Spain is one of the largest pig producers in the world. This work aimed to investigate the genetic and phenotypic features of invasive S. suis isolates recovered in Spain. A panel of 156 clinical isolates recovered from 13 Autonomous Communities, representing the major pig producers, were analysed. MLST and serotyping analysis revealed that most isolates (61.6%) were assigned to ST1 (26.3%), ST123 (18.6%), ST29 (9.6%), and ST3 (7.1%). Interestingly, 34 new STs were identified, indicating the emergence of novel genetic lineages. Serotypes 9 (27.6%) and 1 (21.8%) prevailed, followed by serotypes 7 (12.8%) and 2 (12.2%). Analysis of 13 virulence-associated genes showed significant associations between ST, serotype, virulence patterns, and clinical features, evidencing particular virulence traits associated with genetic clusters. The pangenome was generated, and the core genome was distributed in 7 Bayesian groups where each group included a variable set of over- and under-represented genes of different categories. The study provides comprehensive data and knowledge to improve the design of new vaccines, antimicrobial treatments, and bacterial typing approaches. info:eu-repo/grantAgreement/ES/DGA/LMP58-21 info:eu-repo/grantAgreement/ES/MICINN AEI PID2020-114617RB-100AEI-10.13039-501100011033 info:eu-repo/grantAgreement/ES/UZ/UZ2020-BIO-01 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.5 2024 VETERINARY SCIENCES 10 / 170 = 0.059 2024 Q1 T1 0.914 2024 Veterinary (miscellaneous) 2024 Q1 6.2 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Fernandez, Ana Arnal, José Luis del Pozo, Mateo Amoribieta, Maria Casas de Blas, Ignacio Universidad de Zaragoza (orcid)0000-0002-1204-4356 Jurado, Paula Calvo, Jorge Hugo (orcid)0000-0001-9513-0219 Gottschalk, Marcelo González-Vázquez, Luis Daniel Arenas, Miguel Marín, Clara M. (orcid)0000-0002-1974-9025 Arenas, Jesús Universidad de Zaragoza (orcid)0000-0002-8134-0693 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 55, 1 (2024), [16 pp.] Vet. res. Veterinary Research 0928-4249 4649221 http://zaguan.unizar.es/record/132798/files/texto_completo.pdf Versión publicada 2207719 http://zaguan.unizar.es/record/132798/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:132798 articulos driver 2026-02-17-20:20:24 ARTICLE