000132805 001__ 132805
000132805 005__ 20260217205456.0
000132805 0247_ $$2doi$$a10.1016/j.jclepro.2024.141167
000132805 0248_ $$2sideral$$a137709
000132805 037__ $$aART-2024-137709
000132805 041__ $$aeng
000132805 100__ $$aMondal, S.
000132805 245__ $$aSustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities
000132805 260__ $$c2024
000132805 5060_ $$aAccess copy available to the general public$$fUnrestricted
000132805 5203_ $$aHydrophobic deep eutectic solvents (DESs), a recent class of green solvents, offer 100% atom economy, low cost, potential biodegradability, negligible toxicity and promising bioactivities. In this work, novel aroma-based therapeutic hydrophobic DESs were prepared and dispersed in aqueous media as nanoemulsions to potentiate biomedical applications, where polar media is encountered.
A reusable microengineered stainless-steel isoporous membrane was fabricated by laser drilling technique. Three hydrophobic DESs, namely DES A (menthol and vanillin), DES B (menthol and raspberry ketone), and DES C (thymol and raspberry ketone) were prepared and emulsified in aqueous media by sustainable membrane emulsification technique. The optimised nanoemulsion (DES C-in-water) exhibited a monomodal size distribution with Zavg (size average) of 147 nm and polydispersity index of 0.22.
From the application perspective, the formulated DES-in-water nanoemulsions and their constituents were evaluated for their antibacterial properties against Escherichia coli and Staphylococcus aureus. Additionally, antifungal properties of the DES-based emulsions were reported for the first time by testing them against four fungal strains, Aspergillus fumigatus, Candida albicans, Candida krusei, and Trichophyton mentagrophytes. The nanoemulsions were found to be exhibit antimicrobial effect and lesser quantities of individual compounds were needed in nanoemulsified state to show similar effects. Different 1D and 2D NMR techniques were successfully used to investigate the structural orientation and the inter and intramolecular interactions in the DES and emulsion systems, which revealed a probable cause for higher antimicrobial activity of DES C-based emulsions compared to its peers. Lastly, a synergistic effect of the components in nanoemulsions led to enhanced antimicrobial activities.
000132805 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127847OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PDC2022-133866-I00
000132805 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000132805 590__ $$a10.0$$b2024
000132805 592__ $$a2.174$$b2024
000132805 591__ $$aENGINEERING, ENVIRONMENTAL$$b9 / 83 = 0.108$$c2024$$dQ1$$eT1
000132805 593__ $$aEnvironmental Science (miscellaneous)$$c2024$$dQ1
000132805 591__ $$aGREEN & SUSTAINABLE SCIENCE & TECHNOLOGY$$b12 / 103 = 0.117$$c2024$$dQ1$$eT1
000132805 593__ $$aStrategy and Management$$c2024$$dQ1
000132805 591__ $$aENVIRONMENTAL SCIENCES$$b23 / 376 = 0.061$$c2024$$dQ1$$eT1
000132805 593__ $$aRenewable Energy, Sustainability and the Environment$$c2024$$dQ1
000132805 593__ $$aIndustrial and Manufacturing Engineering$$c2024$$dQ1
000132805 594__ $$a20.7$$b2024
000132805 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000132805 700__ $$aSyed, U.T.
000132805 700__ $$aPinto, E.
000132805 700__ $$aLeonardo, I.C.
000132805 700__ $$0(orcid)0000-0003-1378-0571$$aRomero, P.
000132805 700__ $$aGaspar, F.B.
000132805 700__ $$aCrespo, M.T. Barreto
000132805 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000132805 700__ $$aCrespo, J.G.
000132805 700__ $$aBrazinha, C.
000132805 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000132805 773__ $$g444 (2024), 141167 [13 pp.]$$pJ. clean. prod.$$tJournal of Cleaner Production$$x0959-6526
000132805 8564_ $$s5600961$$uhttps://zaguan.unizar.es/record/132805/files/texto_completo.pdf$$yVersión publicada
000132805 8564_ $$s2507249$$uhttps://zaguan.unizar.es/record/132805/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000132805 909CO $$ooai:zaguan.unizar.es:132805$$particulos$$pdriver
000132805 951__ $$a2026-02-17-20:20:27
000132805 980__ $$aARTICLE