000132851 001__ 132851 000132851 005__ 20250923084416.0 000132851 0247_ $$2doi$$a10.1016/j.pnpbp.2023.110912 000132851 0248_ $$2sideral$$a137699 000132851 037__ $$aART-2024-137699 000132851 041__ $$aeng 000132851 100__ $$aMartínez-Caballero, Maria Ángeles 000132851 245__ $$aBehavioural traits related with resilience or vulnerability to the development of cocaine-induced conditioned place preference after exposure of female mice to vicarious social defeat 000132851 260__ $$c2024 000132851 5060_ $$aAccess copy available to the general public$$fUnrestricted 000132851 5203_ $$aExposure to stress induced by intermittent repeated social defeat (IRSD) increases vulnerability to the development of cocaine-induced conditioned place preference (CPP) among male mice; however, some defeated mice are resilient to these effects of stress. In the present study we evaluated the effects of vicarious IRSD (VIRSD) in female mice and explored behavioural traits that are potentially predictive of resilience. C57BL/6 female mice (n = 28) were exposed to VIRSD, which consisted of the animals witnessing a short experience of social defeat by a male mouse on postnatal day (PND) 47, 50, 53 and 56. The control group (n = 10) was not exposed to stress. Blood samples were collected on PND 47 and 56 for corticosterone and interleukin-6 determinations. On PND 57–58, female mice performed several behavioural tests (elevated plus maze, hole-board, object recognition, social interaction, TST and splash tests). Three weeks later, the effects of cocaine (1.5 mg/kg) on the CPP paradigm were assessed. VIRSD decreased corticosterone levels (on PND 56), increased interleukin-6 levels, enhanced novelty-seeking, improved recognition memory and induced anxiety- and depression-like symptoms. Control and VIRSD female mice did not acquire CPP, although some stressed individuals with certain behavioural traits - including a high novelty-seeking profile or the development of depression-like behaviour in the splash test shortly after VIRSD - acquired cocaine CPP. Our results confirm that some behavioural traits of female mice are associated with vulnerability or resilience to the long-term effects of social stress on cocaine reward, as previously observed in males 000132851 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00 000132851 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000132851 590__ $$a3.9$$b2024 000132851 592__ $$a1.768$$b2024 000132851 591__ $$aCLINICAL NEUROLOGY$$b58 / 285 = 0.204$$c2024$$dQ1$$eT1 000132851 593__ $$aPharmacology$$c2024$$dQ1 000132851 591__ $$aPSYCHIATRY$$b55 / 288 = 0.191$$c2024$$dQ1$$eT1 000132851 593__ $$aBiological Psychiatry$$c2024$$dQ1 000132851 591__ $$aPHARMACOLOGY & PHARMACY$$b88 / 352 = 0.25$$c2024$$dQ1$$eT1 000132851 591__ $$aNEUROSCIENCES$$b86 / 314 = 0.274$$c2024$$dQ2$$eT1 000132851 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000132851 700__ $$aCalpe-López, Claudia 000132851 700__ $$aGarcía-Pardo, Maria Pilar$$uUniversidad de Zaragoza 000132851 700__ $$aArenas, Maria Carmen 000132851 700__ $$ade la Rubia Ortí, Jose Enrique 000132851 700__ $$aBayona-Babiloni, Raquel 000132851 700__ $$aAguilar, Maria Asunción 000132851 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000132851 773__ $$g130 (2024), 110912 [9 pp.]$$pProg. neuro-psychopharmacol. biol. psychiatry$$tProgress in neuro-psychopharmacology & biological psychiatry$$x0278-5846 000132851 8564_ $$s1200795$$uhttps://zaguan.unizar.es/record/132851/files/texto_completo.pdf$$yVersión publicada 000132851 8564_ $$s2454093$$uhttps://zaguan.unizar.es/record/132851/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000132851 909CO $$ooai:zaguan.unizar.es:132851$$particulos$$pdriver 000132851 951__ $$a2025-09-22-14:32:58 000132851 980__ $$aARTICLE