133083 20260217205459.0 doi 10.1016/j.jhep.2024.02.023 sideral 137773 ART-2024-137773 eng Martin-Mateos, Rosa Multidrug-resistant bacterial infections after liver transplantation: prevalence, impact, and risk factors 2024 Background and Aims Multidrug-resistant (MDR) bacterial infections are an increasing healthcare problem worldwide. This study analyzes the incidence, burden, and risk factors associated with MDR infections after liver transplantation (LT). Methods This retrospective, multicenter cohort study included adult patients who underwent LT between January 2017 and January 2020. Risk factors related to pre-LT disease, surgical procedure, and postoperative stay were analyzed. Multivariate logistic regression analysis was performed to identify independent predictors of MDR bacterial infections within the first 90-days after LT. Results We included 1,045 LT (960 patients) performed at nine centers across Spain. The mean age was 56.8 ± 9.3 years, 75.4% (n=782) were male. Alcohol-related liver disease was the most prevalent underlying etiology (43.2.%, n=451). Bacterial infections occurred in 432 patients (41.3%), who presented with a total of 679 episodes of infection (respiratory infections, 19.3%; urinary tract infections, 18.5%; bacteremia, 13.2% and cholangitis 11%, among others). MDR bacteria were isolated in 227 LT (21.7%) (348 episodes). Enterococcus faecium (22.1%), E. coli (18.4%), and Pseudomonas aeruginosa (15.2%) were the most frequently isolated microorganisms. In multivariate analysis, previous intensive care unit admission (0-3 months before LT), previous MDR bacterial infections (0-3 months before LT), and an increasing number of packed red blood cell units transfused during surgery were identified as independent predictors of multi-resistant infections. Mortality at 30, 90, 180, and 365 days was significantly higher in patients with MDR isolates. Conclusion MDR infections are highly prevalent after LT and have a significant impact on prognosis. E. faecium is the most frequently isolated MDR microorganism. New pharmacological and surveillance strategies aimed at preventing MDR infections after LT should be considered for patients with high-risk factors. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 33.0 2024 GASTROENTEROLOGY & HEPATOLOGY 3 / 148 = 0.02 2024 Q1 T1 10.575 2024 Hepatology 2024 Q1 48.5 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez-Arenas, Laura Carvalho-Gomes, Ángela Aceituno, Laia Cadahía, Valle Salcedo, María Magdalena Arias, Ana Lorente Pérez, Sara Universidad de Zaragoza (orcid)0000-0003-4672-8083 Odriozola, Aitor Zamora, Javier Blanes, Marino Len, Óscar Benítez, Laura Campos-Varela, Isabel González Diéguez, María Luisa Rojo Lázaro, Diego Fortún, Jesús Cuadrado, Antonio Marcos Carrasco, Natalia Rodríguez-Perálvarez, Manuel Navascues, Carmen Fábrega, Emilio Serrano, Trinidad Universidad de Zaragoza (orcid)0000-0002-7119-2244 Cuervas Mons, Valentín Rodríguez, Manuel Castells, Lluis Berenguer, Marina Graus, Javier Albillos, Agustín 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 80, 6 (2024), 904-912 J. hepatol. JOURNAL OF HEPATOLOGY 0168-8278 7955975 http://zaguan.unizar.es/record/133083/files/texto_completo.pdf Versión publicada 1581652 http://zaguan.unizar.es/record/133083/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:133083 articulos driver 2026-02-17-20:21:34 ARTICLE