000133094 001__ 133094 000133094 005__ 20250908131410.0 000133094 0247_ $$2doi$$a10.1007/s00238-023-02148-z 000133094 0248_ $$2sideral$$a137832 000133094 037__ $$aART-2024-137832 000133094 041__ $$aeng 000133094 100__ $$aYuste Benavente, Valentin 000133094 245__ $$aThe effect of pitavastatin in an ischemic skin flap model in rats 000133094 260__ $$c2024 000133094 5203_ $$aBackground: The use of statins as a prophylactic drug for ischemic damage in flap surgery has been suggested in recent years, due to their pleiotropic effects. Among the statins, pitavastatin has greater activity and fewer side effects than other forms. In this study, we have analyzed the effect of pitavastatin on the distal ischemic damage of the flaps in a rat flap model. Methods: An experimental study was carried out with 2 groups of 12 Wistar rats. A dorsal McFarlane flap was used in both groups. The first group was given a placebo for 7 days after the intervention while the second group was given the placebo mixed with pitavastatin at a dose of 5 mg/kg per day. At the end of these 7 days, the rats were sacrificed and the necrotic area of each flap was evaluated, as well as the degree of histological damage under microscopy. Results: All 24 rats survived to the end of the study. The control group presented an average necrosis area of 22.77 cm2, compared to 8.14 cm2 in the treatment group. Regarding histological damage, the control group presented an average score of 23.91 points, compared to 15.08 points in the treatment group. We found statistically significant differences in favor of the treatment group for both variables. Conclusions: Our study shows a significant prophylactic effect of pitavastatin over distal ischemia damage on a rat flap model. Therefore, said drug may be useful in planning large flaps. Despite this, new studies in humans are necessary. 000133094 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000133094 592__ $$a0.299$$b2024 000133094 593__ $$aSurgery$$c2024$$dQ3 000133094 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000133094 700__ $$aTrigo Cebrian, Miguel Angel 000133094 700__ $$0(orcid)0009-0007-3530-4513$$aGonzalez Pastor, Cristina$$uUniversidad de Zaragoza 000133094 700__ $$aRodero Roldan, Maria del Mar 000133094 700__ $$aAlos Blanco, Manel 000133094 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000133094 773__ $$g47, 10 (2024), [6 pp.]$$pEur. j. plast. surg.$$tEUROPEAN JOURNAL OF PLASTIC SURGERY$$x0930-343X 000133094 8564_ $$s920136$$uhttps://zaguan.unizar.es/record/133094/files/texto_completo.pdf$$yVersión publicada 000133094 8564_ $$s2332598$$uhttps://zaguan.unizar.es/record/133094/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000133094 909CO $$ooai:zaguan.unizar.es:133094$$particulos$$pdriver 000133094 951__ $$a2025-09-08-12:50:16 000133094 980__ $$aARTICLE