000133101 001__ 133101
000133101 005__ 20260217205500.0
000133101 0247_ $$2doi$$a10.1016/j.jpsychires.2024.02.044
000133101 0248_ $$2sideral$$a137874
000133101 037__ $$aART-2024-137874
000133101 041__ $$aeng
000133101 100__ $$aBioque, Miquel
000133101 245__ $$aAssociation between neutrophil to lymphocyte ratio and inflammatory biomarkers in patients with a first episode of psychosis
000133101 260__ $$c2024
000133101 5203_ $$aNeutrophil to lymphocyte ratio (NLR) has been proposed as an emerging marker of the immune system alterations in psychotic disorders. However, it is not entirely clear whether NLR elevation is a characteristic of the psychotic disorder itself, which inflammatory pathways activation is detecting, or which possible confounding variables could alter its interpretation.
We aimed to analyze the relationship of NLR values with a panel of inflammatory and oxidative/nitrosative stress biomarkers and main potential confounding factors in a well-characterized cohort of 97 patients with a first episode of psychosis (FEP) and 77 matched healthy controls (HC).
In the FEP group, NLR values presented a moderate, positive correlation with the pro-inflammatory mediator Prostaglandin E2 levels (r = 0.36, p < 0.001) and a small but significant, positive correlation with cannabis use (r = 0.25, p = 0.017). After controlling for cannabis use, the association between NLR and PGE2 remained significant (beta = 0.31, p = 0.012). In the HC group, NLR values negatively correlated with body mass index (BMI, r = −0.24, p = 0.035) and positively correlated with tobacco use (r = 0.25, p = 0.031).
These findings support a relationship between the elevation of NLR values and an elevated expression of proinflammatory pathways related to stress response in patients with a FEP. In addition, our study highlights the importance of considering variables such as cannabis or tobacco consumption, and BMI when interpreting the results of studies aimed to establish a clinical use of NLR. These considerations may help future research to use NLR as a reliable biomarker to determine immune system status in this population.
000133101 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CD20-00177$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI08-0208$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MICIU-ISCIII-FEDER/PI14-00612
000133101 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000133101 590__ $$a3.2$$b2024
000133101 592__ $$a1.487$$b2024
000133101 591__ $$aPSYCHIATRY$$b91 / 288 = 0.316$$c2024$$dQ2$$eT1
000133101 593__ $$aPsychiatry and Mental Health$$c2024$$dQ1
000133101 591__ $$aPSYCHIATRY$$b91 / 288 = 0.316$$c2024$$dQ2$$eT1
000133101 593__ $$aBiological Psychiatry$$c2024$$dQ1
000133101 594__ $$a7.4$$b2024
000133101 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133101 700__ $$aLlorca-Bofí, Vicent
000133101 700__ $$aSalmerón, Sergi
000133101 700__ $$aGarcía-Bueno, Borja
000133101 700__ $$aMacDowell, Karina S.
000133101 700__ $$aMoreno, Carmen
000133101 700__ $$aSáiz, Pilar A.
000133101 700__ $$aGonzález-Pinto, Ana
000133101 700__ $$aHidalgo-Figueroa, María
000133101 700__ $$aBarcones, María Fe
000133101 700__ $$aRodriguez-Jimenez, Roberto
000133101 700__ $$aBernardo, Miquel
000133101 700__ $$aLeza, Juan Carlos
000133101 773__ $$g172 (2024), 334-339$$pJ. Psychiatr. Res.$$tJOURNAL OF PSYCHIATRIC RESEARCH$$x0022-3956
000133101 8564_ $$s395096$$uhttps://zaguan.unizar.es/record/133101/files/texto_completo.pdf$$yVersión publicada
000133101 8564_ $$s2324186$$uhttps://zaguan.unizar.es/record/133101/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133101 909CO $$ooai:zaguan.unizar.es:133101$$particulos$$pdriver
000133101 951__ $$a2026-02-17-20:21:41
000133101 980__ $$aARTICLE