000133124 001__ 133124
000133124 005__ 20250923084414.0
000133124 0247_ $$2doi$$a10.1016/j.jmbbm.2024.106413
000133124 0248_ $$2sideral$$a137781
000133124 037__ $$aART-2024-137781
000133124 041__ $$aeng
000133124 100__ $$aRedaelli, Elena$$uUniversidad de Zaragoza
000133124 245__ $$aImproving early detection of keratoconus by Non Contact Tonometry. A computational study and new biomarkers proposal
000133124 260__ $$c2024
000133124 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133124 5203_ $$aKeratoconus is a progressive ocular disorder affecting the corneal tissue, leading to irregular astigmatism and decreased visual acuity. The architectural organization of corneal tissue is altered in keratoconus, however, data from ex vivo testing of biomechanical properties of keratoconic corneas are limited and it is unclear how their results relate to true mechanical properties in vivo. This study explores the mechanical properties of keratoconic corneas through numerical simulations of non-contact tonometry (NCT) reproducing the clinical test of the Corvis ST device. Three sensitivity analyses were conducted to assess the impact of corneal material properties, size, and location of the pathological area on NCT results. Additionally, novel asymmetry-based indices were proposed to better characterize corneal deformations and improve the diagnosis of keratoconus. Our results show that the weakening of corneal material properties leads to increased deformation amplitude and altered biomechanical response. Furthermore, asymmetry indices offer valuable information for locating the pathological tissue. These findings suggest that adjusting the Corvis ST operation, such as a camera rotation, could enhance keratoconus detection and provide insights into the relative position of the affected area. Future research could explore the application of these indices in detecting early-stage keratoconus and assessing the fellow eye's risk for developing the pathology
000133124 536__ $$9info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN
000133124 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133124 590__ $$a3.5$$b2024
000133124 592__ $$a0.75$$b2024
000133124 591__ $$aENGINEERING, BIOMEDICAL$$b54 / 124 = 0.435$$c2024$$dQ2$$eT2
000133124 593__ $$aBiomaterials$$c2024$$dQ2
000133124 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b34 / 55 = 0.618$$c2024$$dQ3$$eT2
000133124 593__ $$aMechanics of Materials$$c2024$$dQ2
000133124 593__ $$aBiomedical Engineering$$c2024$$dQ2
000133124 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133124 700__ $$aNana, Michael
000133124 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, Begoña$$uUniversidad de Zaragoza
000133124 700__ $$aRodríguez Matas, José Félix
000133124 700__ $$aLuraghi, Giulia
000133124 700__ $$aRozema, Jos
000133124 700__ $$0(orcid)0000-0002-6870-0594$$aGrasa, Jorge$$uUniversidad de Zaragoza
000133124 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000133124 773__ $$g152 (2024), 106413 [10 pp.]$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000133124 8564_ $$s2831506$$uhttps://zaguan.unizar.es/record/133124/files/texto_completo.pdf$$yVersión publicada
000133124 8564_ $$s2728113$$uhttps://zaguan.unizar.es/record/133124/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133124 909CO $$ooai:zaguan.unizar.es:133124$$particulos$$pdriver
000133124 951__ $$a2025-09-22-14:31:42
000133124 980__ $$aARTICLE