133124 20260217205513.0 doi 10.1016/j.jmbbm.2024.106413 sideral 137781 ART-2024-137781 eng Redaelli, Elena Universidad de Zaragoza Improving early detection of keratoconus by Non Contact Tonometry. A computational study and new biomarkers proposal 2024 Access copy available to the general public Unrestricted Keratoconus is a progressive ocular disorder affecting the corneal tissue, leading to irregular astigmatism and decreased visual acuity. The architectural organization of corneal tissue is altered in keratoconus, however, data from ex vivo testing of biomechanical properties of keratoconic corneas are limited and it is unclear how their results relate to true mechanical properties in vivo. This study explores the mechanical properties of keratoconic corneas through numerical simulations of non-contact tonometry (NCT) reproducing the clinical test of the Corvis ST device. Three sensitivity analyses were conducted to assess the impact of corneal material properties, size, and location of the pathological area on NCT results. Additionally, novel asymmetry-based indices were proposed to better characterize corneal deformations and improve the diagnosis of keratoconus. Our results show that the weakening of corneal material properties leads to increased deformation amplitude and altered biomechanical response. Furthermore, asymmetry indices offer valuable information for locating the pathological tissue. These findings suggest that adjusting the Corvis ST operation, such as a camera rotation, could enhance keratoconus detection and provide insights into the relative position of the affected area. Future research could explore the application of these indices in detecting early-stage keratoconus and assessing the fellow eye's risk for developing the pathology info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U27 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.5 2024 ENGINEERING, BIOMEDICAL 54 / 124 = 0.435 2024 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 34 / 55 = 0.618 2024 Q3 T2 0.75 2024 Biomaterials 2024 Q2 Mechanics of Materials 2024 Q2 Biomedical Engineering 2024 Q2 7.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nana, Michael Calvo, Begoña Universidad de Zaragoza (orcid)0000-0001-9713-1813 Rodríguez Matas, José Félix Luraghi, Giulia Rozema, Jos Grasa, Jorge Universidad de Zaragoza (orcid)0000-0002-6870-0594 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 152 (2024), 106413 [10 pp.] J. mech. behav. boomed. mater. Journal of the Mechanical Behavior of Biomedical Materials 1751-6161 2831506 http://zaguan.unizar.es/record/133124/files/texto_completo.pdf Versión publicada 2728113 http://zaguan.unizar.es/record/133124/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:133124 articulos driver 2026-02-17-20:25:45 ARTICLE