000133163 001__ 133163
000133163 005__ 20240322124130.0
000133163 0247_ $$2doi$$a10.3389/fpubh.2024.1302688
000133163 0248_ $$2sideral$$a137871
000133163 037__ $$aART-2024-137871
000133163 041__ $$aeng
000133163 100__ $$aTovar, Mario$$uUniversidad de Zaragoza
000133163 245__ $$aModel-based impact evaluation of new tuberculosis vaccines in aging populations under different modeling scenarios: the case of China
000133163 260__ $$c2024
000133163 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133163 5203_ $$aIntroductionThe slow descent in TB burden, the COVID-19 pandemic, along with the rise of multidrug-resistant strains of Mycobacterium tuberculosis, seriously threaten TB control and the goals of the End TB strategy. To fight back, several vaccine candidates are under development, with some of them undergoing the phases 2B and 3 of the development pipeline. The impact of these vaccines on the general population needs to be addressed using disease-transmission models, and, in a country like China, which last year ranked third in number of cases worldwide, and where the population is aging at a fast pace, the impact of TB vaccination campaigns may depend heavily upon the age of targeted populations, the mechanistic descriptions of the TB vaccines and the coupling between TB dynamics and demographic evolution.MethodsIn this work, we studied the potential impact of a new TB vaccine in China targeting adolescents (15–19 y.o.) or older adults (60–64 y.o.), according to varying vaccine descriptions that represent reasonable mechanisms of action leading to prevention of disease, or prevention of recurrence, each of them targetting specific routes to TB disease. To measure the influence of the description of the coupling between transmission dynamics and aging in TB transmission models, we explored two different approaches to compute the evolution of the contact matrices, which relate to the spreading among different age strata.ResultsOur findings highlight the dependence of model-based impact estimates on vaccine profiles and the chosen modeling approach for describing the evolution of contact matrices. Our results also show, in line with previous modeling works, that older adult vaccination is a suitable option in China to reduce the incidence of TB as long as the vaccine is able to protect already exposed individuals.DiscussionThis study underscores the importance of considering vaccine characteristics and demographic dynamics in shaping TB control strategies. In this sense, older adult vaccination emerges as a promising avenue for mitigating TB transmission in China but also remarks the need for tailored intervention strategies aligned with demographic trends.
000133163 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B49-23R-NeuroBioSys$$9info:eu-repo/grantAgreement/ES/DGA/E36-23R-FENOL$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-106859GA-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-115800GB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC-2017-23560
000133163 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133163 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133163 700__ $$0(orcid)0000-0002-2980-9685$$aSanz, Joaquín$$uUniversidad de Zaragoza
000133163 700__ $$0(orcid)0000-0002-0895-1893$$aMoreno, Yamir$$uUniversidad de Zaragoza
000133163 7102_ $$12004$$2405$$aUniversidad de Zaragoza$$bDpto. Física Teórica$$cÁrea Física Teórica
000133163 773__ $$g12 (2024), 1302688 [11 pp.]$$pFront. public health.$$tFrontiers in public health$$x2296-2565
000133163 8564_ $$s1432277$$uhttps://zaguan.unizar.es/record/133163/files/texto_completo.pdf$$yVersión publicada
000133163 8564_ $$s2043748$$uhttps://zaguan.unizar.es/record/133163/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133163 909CO $$ooai:zaguan.unizar.es:133163$$particulos$$pdriver
000133163 951__ $$a2024-03-22-09:48:33
000133163 980__ $$aARTICLE