000133228 001__ 133228
000133228 005__ 20240410085328.0
000133228 0247_ $$2doi$$a10.3390/biom14030377
000133228 0248_ $$2sideral$$a137879
000133228 037__ $$aART-2024-137879
000133228 041__ $$aeng
000133228 100__ $$0(orcid)0009-0008-3380-0465$$aGascón, Elisa$$uUniversidad de Zaragoza
000133228 245__ $$aSporadic amyotrophic lateral sclerosis skeletal muscle transcriptome analysis: a comprehensive examination of differentially expressed genes
000133228 260__ $$c2024
000133228 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133228 5203_ $$aAmyotrophic lateral sclerosis (ALS) that comprises sporadic (sALS) and familial (fALS) cases, is a devastating neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle atrophy and various clinical manifestations. However, the complex underlying mechanisms affecting this disease are not yet known. On the other hand, there is also no good prognosis of the disease due to the lack of biomarkers and therapeutic targets. Therefore, in this study, by means of bioinformatics analysis, sALS-affected muscle tissue was analyzed using the GEO GSE41414 dataset, identifying 397 differentially expressed genes (DEGs). Functional analysis revealed 320 up-regulated DEGs associated with muscle development and 77 down-regulated DEGs linked to energy metabolism. Protein–protein interaction network analysis identified 20 hub genes, including EIF4A1, HNRNPR and NDUFA4. Furthermore, miRNA target gene networks revealed 17 miRNAs linked to hub genes, with hsa-mir-206, hsa-mir-133b and hsa-mir-100-5p having been previously implicated in ALS. This study presents new potential biomarkers and therapeutic targets for ALS by correlating the information obtained with a comprehensive literature review, providing new potential targets to study their role in ALS.
000133228 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A19-23R$$9info:eu-repo/grantAgreement/ES/FIS/PI17-00949
000133228 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133228 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133228 700__ $$0(orcid)0000-0001-5740-0185$$aZaragoza, Pilar$$uUniversidad de Zaragoza
000133228 700__ $$0(orcid)0000-0001-5193-7782$$aCalvo, Ana Cristina$$uUniversidad de Zaragoza
000133228 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, Rosario$$uUniversidad de Zaragoza
000133228 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000133228 773__ $$g14, 3 (2024), 377 [13 pp.]$$tBiomolecules$$x2218-273X
000133228 8564_ $$s3378033$$uhttps://zaguan.unizar.es/record/133228/files/texto_completo.pdf$$yVersión publicada
000133228 8564_ $$s2662202$$uhttps://zaguan.unizar.es/record/133228/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133228 909CO $$ooai:zaguan.unizar.es:133228$$particulos$$pdriver
000133228 951__ $$a2024-04-10-08:35:49
000133228 980__ $$aARTICLE