000133232 001__ 133232
000133232 005__ 20240410085328.0
000133232 0247_ $$2doi$$a10.1016/j.vetmic.2024.110037
000133232 0248_ $$2sideral$$a137938
000133232 037__ $$aART-2024-137938
000133232 041__ $$aeng
000133232 100__ $$aGómez, Álex$$uUniversidad de Zaragoza
000133232 245__ $$aUse of a local anaesthetic and antiseptic wound formulation for the treatment of lambs naturally infected with Orf virus
000133232 260__ $$c2024
000133232 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133232 5203_ $$aContagious ecthyma (CE) is a worldwide highly contagious zoonotic viral skin disease of sheep and goats. Treatment for Orf virus (ORFV) infection usually involves topical and oral antibiotics. An anaesthetic and antiseptic topical gel (Multisolfen® or Tri-Solfen®; MS®, Medical Ethics, Australia) has been documented as an efficacious therapy for lesions from mucosal and epithelial viral infections in ruminants. The present study tested a new treatment protocol of MS® for CE therapy on-farm in 150 lambs naturally infected with ORFV. Lambs were divided into three cohorts of 50 lambs each (C, D and E). Cohort C was treated with MS® 3 times with an interval of 3 days between treatments, cohort D was treated daily with hypochlorous acid, whilst cohort E served as untreated controls. The lambs were examined clinically every two days, weight measured weekly, with whole blood and sterile swabs from ORFV lesions collected for haematological analysis and specific ORFV PCR. Cohort C presented fewer lambs displaying ORFV-associated lesions than other cohorts at different times of the experiment. Further, lesions treated with MS® were milder compared with other cohorts. However, following cessation of therapy, most of the lambs again developed ORFV-associated lesions. No differences between cohorts were observed in weight, haematological and PCR results. These findings suggest that topical treatment with MS® is effective for CE in field conditions, especially in the first stages of the clinical course, although treatment with MS® may need to be extended a minimum of 4 weeks.
000133232 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/Construyendo Aragón 2016–2020-A15-17R
000133232 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133232 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133232 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0001-5026-5144$$aTejedor, María Teresa$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, Marta$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-2724-2785$$aRamos, Juan José$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-8474-2831$$aRuiz, Héctor$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-0313-5926$$aOrtín, Aurora$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000133232 700__ $$aReina, Ramsés
000133232 700__ $$aQuílez, Pablo$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-4557-6033$$aNavarro, Teresa$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0003-2957-1379$$aVerde, Maite$$uUniversidad de Zaragoza
000133232 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza
000133232 700__ $$aWindsor, Peter Andrew
000133232 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000133232 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000133232 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000133232 773__ $$g292 (2024), 110037 [7 pp.]$$pVet. microbiol.$$tVeterinary Microbiology$$x0378-1135
000133232 8564_ $$s629841$$uhttps://zaguan.unizar.es/record/133232/files/texto_completo.pdf$$yVersión publicada
000133232 8564_ $$s2378996$$uhttps://zaguan.unizar.es/record/133232/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133232 909CO $$ooai:zaguan.unizar.es:133232$$particulos$$pdriver
000133232 951__ $$a2024-04-10-08:35:54
000133232 980__ $$aARTICLE