133277 20260217205504.0 doi 10.1371/journal.pone.0295652 sideral 138016 ART-2024-138016 eng Bergues, Jesús M. Organization of two kinesins in a two-dimensional microtubule network 2024 Access copy available to the general public Unrestricted In intracellular active transport, molecular motors are responsible for moving biological cargo along networks of microtubules that serve as scaffolds. Cargo dynamics can be modified by different features of microtubule networks such as geometry, density, orientation modifications. Also, the dynamical behaviour of the molecular motors is determined by the microtubule network and by the individual and/or collective action of the motors. For example, unlike single kinesins, the mechanistic behavior of multiple kinesins varies from one experiment to another. However, the reasons for this experimental variability are unknown. Here we show theoretically how non-radial and quasi-radial microtubule architectures modify the collective behavior of two kinesins attached on a cargo. We found out under which structural conditions transport is most efficient and the most likely way in which kinesins are organized in active transport. In addition, with motor activity, mean intermotor distance and motor organization, we determined the character of the collective interaction of the kinesins during transport. Our results demonstrate that two-dimensional microtubule structures promote branching due to crossovers that alter directionality in cargo movement and may provide insight into the collective organization of the motors. Our article offers a perspective to analyze how the two-dimensional network can modify the cargo-motor dynamics for the case in which multiple motors move in different directions as in the case of kinesin and dynein. info:eu-repo/grantAgreement/ES/DGA/E36-23R-FENOL info:eu-repo/grantAgreement/ES/MINECO/PID2020-113582GB-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 2.6 2024 MULTIDISCIPLINARY SCIENCES 44 / 136 = 0.324 2024 Q2 T1 0.803 2024 Multidisciplinary 2024 Q1 5.4 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Falo, Fernando Universidad de Zaragoza (orcid)0000-0002-9551-624X 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 19, 3 (2024), e0295652 [17 pp.] PLoS One PLoS ONE 1932-6203 4407676 http://zaguan.unizar.es/record/133277/files/texto_completo.pdf Versión publicada 2289371 http://zaguan.unizar.es/record/133277/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:133277 articulos driver 2026-02-17-20:22:53 ARTICLE