133298 20260217205514.0 doi 10.3390/nu16050639 sideral 137948 ART-2024-137948 eng González-Lamuño, Domingo Supplementation for Performance and Health in Patients with Phenylketonuria: An Exercise-Based Approach to Improving Dietary Adherence 2024 Access copy available to the general public Unrestricted Supplementation is crucial for improving performance and health in phenylketonuria (PKU) patients, who face dietary challenges. Proteins are vital for athletes, supporting muscle growth, minimizing catabolism, and aiding muscle repair and glycogen replenishment post-exercise. However, PKU individuals must limit phenylalanine (Phe) intake, requiring supplementation with Phe-free amino acids or glycomacropeptides. Tailored to meet nutritional needs, these substitutes lack Phe but fulfill protein requirements. Due to limited supplement availability, athletes with PKU may need higher protein intake. Various factors affect tolerated Phe levels, including supplement quantity and age. Adhering to supplement regimens optimizes performance and addresses PKU challenges. Strategically-timed protein substitutes can safely enhance muscle synthesis and sports performance. Individualized intake is essential for optimal outcomes, recognizing proteins’ multifaceted role. Here, we explore protein substitute supplementation in PKU patients within the context of physical activity, considering limited evidence. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.0 2024 NUTRITION & DIETETICS 17 / 113 = 0.15 2024 Q1 T1 1.473 2024 Nutrition and Dietetics 2024 Q1 Food Science 2024 Q1 9.1 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Morencos, Carmenmelina Arrieta, Francisco J. Venegas, Eva Vicente-Rodríguez, Germán Universidad de Zaragoza (orcid)0000-0002-4303-4097 Casajús, José Antonio Universidad de Zaragoza (orcid)0000-0002-7215-6931 Couce, Maria Luz Aldámiz-Echevarría, Luís 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 16, 5 (2024), 639 [15 pp.] Nutrients Nutrients 2072-6643 305054 http://zaguan.unizar.es/record/133298/files/texto_completo.pdf Versión publicada 2648602 http://zaguan.unizar.es/record/133298/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:133298 articulos driver 2026-02-17-20:26:26 ARTICLE