000133310 001__ 133310
000133310 005__ 20260217205515.0
000133310 0247_ $$2doi$$a10.1371/journal.pbio.3002546
000133310 0248_ $$2sideral$$a138019
000133310 037__ $$aART-2024-138019
000133310 041__ $$aeng
000133310 100__ $$0(orcid)0000-0002-1960-2672$$aSarasa-Buisan, Cristina
000133310 245__ $$aAn ancient bacterial zinc acquisition system identified from a cyanobacterial exoproteome
000133310 260__ $$c2024
000133310 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133310 5203_ $$aBacteria have developed fine-tuned responses to cope with potential zinc limitation. The Zur protein is a key player in coordinating this response in most species. Comparative proteomics conducted on the cyanobacterium Anabaena highlighted the more abundant proteins in a zur mutant compared to the wild type. Experimental evidence showed that the exoprotein ZepA mediates zinc uptake. Genomic context of the zepA gene and protein structure prediction provided additional insights on the regulation and putative function of ZepA homologs. Phylogenetic analysis suggests that ZepA represents a primordial system for zinc acquisition that has been conserved for billions of years in a handful of species from distant bacterial lineages. Furthermore, these results show that Zur may have been one of the first regulators of the FUR family to evolve, consistent with the scarcity of zinc in the ecosystems of the Archean eon.
000133310 536__ $$9info:eu-repo/grantAgreement/EUR/AEI/PID2021-128477NB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E35-20R$$9info:eu-repo/grantAgreement/ES/MCIU/PID2019-104889GB-I00
000133310 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000133310 590__ $$a7.2$$b2024
000133310 592__ $$a2.691$$b2024
000133310 591__ $$aBIOLOGY$$b6 / 107 = 0.056$$c2024$$dQ1$$eT1
000133310 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2024$$dQ1
000133310 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b40 / 320 = 0.125$$c2024$$dQ1$$eT1
000133310 593__ $$aNeuroscience (miscellaneous)$$c2024$$dQ1
000133310 593__ $$aImmunology and Microbiology (miscellaneous)$$c2024$$dQ1
000133310 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2024$$dQ1
000133310 594__ $$a10.3$$b2024
000133310 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133310 700__ $$aOchoa de Alda, Jesús A. G.
000133310 700__ $$aVelázquez-Suárez, Cristina
000133310 700__ $$aRubio, Miguel Ángel
000133310 700__ $$aGómez-Baena, Guadalupe
000133310 700__ $$0(orcid)0000-0001-8644-4574$$aFillat, María F.$$uUniversidad de Zaragoza
000133310 700__ $$aLuque, Ignacio
000133310 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000133310 773__ $$g22, 3 (2024), e3002546 [33 pp.]$$pPLOS BIOL$$tPLOS BIOLOGY$$x1544-9173
000133310 8564_ $$s4012335$$uhttps://zaguan.unizar.es/record/133310/files/texto_completo.pdf$$yVersión publicada
000133310 8564_ $$s2442023$$uhttps://zaguan.unizar.es/record/133310/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133310 909CO $$ooai:zaguan.unizar.es:133310$$particulos$$pdriver
000133310 951__ $$a2026-02-17-20:26:40
000133310 980__ $$aARTICLE