000133344 001__ 133344
000133344 005__ 20240412150654.0
000133344 0247_ $$2doi$$a10.1016/j.reprotox.2024.108581
000133344 0248_ $$2sideral$$a138039
000133344 037__ $$aART-2024-138039
000133344 041__ $$aeng
000133344 100__ $$0(orcid)0000-0001-5603-3045$$aBarrio, Eva$$uUniversidad de Zaragoza
000133344 245__ $$aEpigenetic modifications in the ferroptosis pathway in cord blood cells from newborns of smoking mothers and their influence on fetal growth
000133344 260__ $$c2024
000133344 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133344 5203_ $$aMaternal smoking during pregnancy increases oxidative stress and decreases antioxidant capacity in newborns. Uncontrolled oxidative stress plays a role in fetal development disorders and in adverse perinatal outcomes. In order to identify molecular pathways involved in low fetal growth, epigenetic modifications in newborns of smoking and non-smoking mothers were examined. Low birth weight newborns of mothers who smoked more than 10 cigarettes per day during the first trimester of pregnancy and normal birth weight newborns of mothers who did not smoke during pregnancy were included in the study. DNA was extracted from umbilical cord blood of term newborns. 125 differentially methylated regions were identified by MeDIP-Seq. Functional analysis revealed several pathways, such as ferroptosis, that were enriched in differentially methylated genes after prenatal smoke exposure. GPX4 and PCBP1 were found to be hypermethylated and associated with low fetal growth. These epigenetic modifications in ferroptosis pathway genes in newborns of smoking mothers can potentially contribute to intrauterine growth restriction through the induction of cell death via lipid peroxidation of cell membranes. The identification of epigenetic modifications in the ferroptosis pathway sheds light on the potential mechanisms underlying the pathophysiology of low birth weight in infants born to smoking mothers.
000133344 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B19-20R
000133344 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000133344 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133344 700__ $$0(orcid)0000-0003-0691-0251$$aLerma-Puertas, Diego$$uUniversidad de Zaragoza
000133344 700__ $$aJaulín-Pueyo, José Javier
000133344 700__ $$0(orcid)0000-0003-2832-2266$$aLabarta, José Ignacio$$uUniversidad de Zaragoza
000133344 700__ $$0(orcid)0000-0003-0335-0404$$aGascón-Catalán, Ana$$uUniversidad de Zaragoza
000133344 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000133344 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000133344 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000133344 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000133344 773__ $$g125 (2024), 108581 [8 pp.]$$pReprod. toxicol.$$tREPRODUCTIVE TOXICOLOGY$$x0890-6238
000133344 8564_ $$s1022556$$uhttps://zaguan.unizar.es/record/133344/files/texto_completo.pdf$$yVersión publicada
000133344 8564_ $$s2600586$$uhttps://zaguan.unizar.es/record/133344/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133344 909CO $$ooai:zaguan.unizar.es:133344$$particulos$$pdriver
000133344 951__ $$a2024-04-12-13:58:22
000133344 980__ $$aARTICLE