000133374 001__ 133374
000133374 005__ 20260112133213.0
000133374 0247_ $$2doi$$a10.1016/j.jhazmat.2024.134030
000133374 0248_ $$2sideral$$a138053
000133374 037__ $$aART-2024-138053
000133374 041__ $$aeng
000133374 100__ $$aDomenech, Josefa
000133374 245__ $$aIn vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics
000133374 260__ $$c2024
000133374 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133374 5203_ $$aContinuous exposure to plastic pollutants may have serious consequences on human health. However, most toxicity assessments focus on non-environmentally relevant particles and rarely investigate long-term effects such as cancer induction. The present study assessed the carcinogenic potential of two secondary nanoplastics: polyethylene terephthalate (PET) particles generated from plastic bottles, and a biodegradable polylactic acid material, as respective examples of environmentally existing particles and new bioplastics. Pristine polystyrene nanoplastics were also included for comparison. A broad concentration range (6.25–200 μg/mL) of each nanoplastic was tested in both the initiation and promotion conditions of the regulatory assessment-accepted in vitro Bhas 42 cell transformation assay. Parallel cultures allowed confirmation of the efficient cellular internalisation of the three nanoplastics. Cell growth was enhanced by polystyrene in the initiation assay, and by PET in both conditions. Moreover, the number of transformed foci was significantly increased only by the highest PET concentration in the promotion assay, which also showed dose-dependency, indicating that nano PET can act as a non-genotoxic tumour promotor. Together, these findings support the carcinogenic risk assessment of nanoplastics and raise concerns regarding whether real-life co-exposure of PET nanoplastics and other environmental pollutants may result in synergistic transformation capacities.
000133374 536__ $$9info:eu-repo/grantAgreement/EC/H2020/965196/EU/Innovative tools to study the impact and mode of action of micro and nanoplastics on human health: towards a knowledge base for risk assessment/PLASTICHEAL$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965196-PLASTICHEAL$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-116789-RB-C43
000133374 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000133374 590__ $$a11.3$$b2024
000133374 592__ $$a3.078$$b2024
000133374 591__ $$aENVIRONMENTAL SCIENCES$$b19 / 374 = 0.051$$c2024$$dQ1$$eT1
000133374 593__ $$aEnvironmental Chemistry$$c2024$$dQ1
000133374 591__ $$aENGINEERING, ENVIRONMENTAL$$b5 / 83 = 0.06$$c2024$$dQ1$$eT1
000133374 593__ $$aEnvironmental Engineering$$c2024$$dQ1
000133374 593__ $$aWaste Management and Disposal$$c2024$$dQ1
000133374 593__ $$aPollution$$c2024$$dQ1
000133374 593__ $$aHealth, Toxicology and Mutagenesis$$c2024$$dQ1
000133374 594__ $$a24.6$$b2024
000133374 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133374 700__ $$aVillacorta, Aliro
000133374 700__ $$aFerrer, Juan Francisco
000133374 700__ $$aLlorens-Chiralt, Raquel
000133374 700__ $$aMarcos, Ricard
000133374 700__ $$aHernández, Alba
000133374 700__ $$0(orcid)0000-0003-2936-242X$$aCatalán, Julia$$uUniversidad de Zaragoza
000133374 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000133374 773__ $$g469 (2024), 134030 [14 pp.]$$pJ. hazard. mater.$$tJournal of Hazardous Materials$$x0304-3894
000133374 8564_ $$s7710051$$uhttps://zaguan.unizar.es/record/133374/files/texto_completo.pdf$$yVersión publicada
000133374 8564_ $$s2008953$$uhttps://zaguan.unizar.es/record/133374/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133374 909CO $$ooai:zaguan.unizar.es:133374$$particulos$$pdriver
000133374 951__ $$a2026-01-12-12:42:59
000133374 980__ $$aARTICLE