000133411 001__ 133411
000133411 005__ 20240412150654.0
000133411 0247_ $$2doi$$a10.1016/j.device.2023.100224
000133411 0248_ $$2sideral$$a138070
000133411 037__ $$aART-2024-138070
000133411 041__ $$aeng
000133411 100__ $$aMiralles-Comins, Sara
000133411 245__ $$aDevelopment of high-resolution 3D printable polymerizable ionic liquids for antimicrobial applications
000133411 260__ $$c2024
000133411 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133411 5203_ $$aThe bigger picture
In the quest to address global antibiotic resistance, this study pioneers 3D-printable antimicrobial polymeric scaffolds with embedded copper-based nanoparticles. A polymeric formulation based on polymeric ionic liquids has been carefully designed to overcome nanoparticle stabilization challenges, while being optimized for 3D printing. Customized formulations for digital light processing and masked stereolithography-based 3D printing are introduced, resulting in high-resolution materials with potent antimicrobial properties. Successful 3D printing of a device analogous to a medical stent demonstrated their efficacy against the growth of S. epidermidis bacteria. This research underscores additive manufacturing’s transformative potential for high-resolution devices, contributing significantly to a critical global health concern. It establishes a foundation for diverse antimicrobial solutions, marking a substantial advancement in the field.
Summary
In recent years, 3D printing has undergone a significant transformation, expanding beyond its initial niche applications, such as rapid prototyping and hobbyist projects. This evolution has been characterized by advancements in equipment, software, and, most notably, materials. However, the development of materials that present high-resolution and advanced tunable functionalities is still a challenge. Herein, we report the development of modular 3D-printable antimicrobial polymeric ionic liquid (PIL) scaffolds with in situ formation of copper-based nanoparticles within the polymeric matrix (Cu@PILs). A variety of formulations were specially designed and optimized to be printed by digital light processing and masked stereolithography techniques at high resolution. The antimicrobial activity as well as the biocompatibility of the different formulations was tested, changing the monomeric ionic liquid and the photoinitiator. Tailor-made objects were successfully manufactured, and as a demonstrator, a geometry compatible with a medical stent was printed.
000133411 536__ $$9info:eu-repo/grantAgreement/EC/H2020/101026335/EU/Efficient CO2 capture and valorisation with 3D printed catalytic reactors/3DPILcat$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101026335-3DPILcat$$9info:eu-repo/grantAgreement/ES/MICINN-AEI/PRTR-C17.I1$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-141276OB-I00
000133411 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133411 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133411 700__ $$aZanatta, Marcileia
000133411 700__ $$0(orcid)0000-0002-7407-6177$$aGarcía Embid, Sonia
000133411 700__ $$0(orcid)0000-0002-4261-9480$$aAlleva, María
000133411 700__ $$aChiappone, Annalisa
000133411 700__ $$aRoppolo, Ignazio
000133411 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, Scott G.
000133411 700__ $$aSans, Victor
000133411 773__ $$g2, 2 (2024), 100224 [12 pp.]$$tDevice$$x2666-9986
000133411 8564_ $$s4473196$$uhttps://zaguan.unizar.es/record/133411/files/texto_completo.pdf$$yVersión publicada
000133411 8564_ $$s1433891$$uhttps://zaguan.unizar.es/record/133411/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133411 909CO $$ooai:zaguan.unizar.es:133411$$particulos$$pdriver
000133411 951__ $$a2024-04-12-13:59:47
000133411 980__ $$aARTICLE