000133424 001__ 133424
000133424 005__ 20250923084431.0
000133424 0247_ $$2doi$$a10.3390/cancers16061144
000133424 0248_ $$2sideral$$a138136
000133424 037__ $$aART-2024-138136
000133424 041__ $$aeng
000133424 100__ $$aMoratiel-Pellitero, Alba
000133424 245__ $$aBiomarkers of immunotherapy response in patients with non-small-cell lung cancer: microbiota composition, short-chain fatty acids, and intestinal permeability
000133424 260__ $$c2024
000133424 5060_ $$aAccess copy available to the general public$$fUnrestricted
000133424 5203_ $$aImmune checkpoint inhibitors have been proposed as the standard treatment for different stages of non-small-cell lung cancer in multiple indications. Not all patients benefit from these treatments, however, and certain patients develop immune-related adverse events. Although the search for predictors of response to these drugs is a major field of research, these issues have yet to be resolved. It has been postulated that microbiota could play a relevant role in conditioning the response to cancer treatments; however, the human factor of intestinal permeability also needs to be considered as it is closely related to the regulation of host–microbiota interaction. In this article, we analyzed the possible relationship between the response to immune checkpoint inhibitors and the onset of immune-related adverse events, gut microbiota status, and intestinal membrane permeability. In a pioneering step, we also measured short-chain fatty acid content in feces. Although the correlation analyses failed to identify predictive biomarkers, even when all variables were integrated, our patients’ microbial gut ecosystems were rich and diverse, and the intestinal barrier’s integrity was preserved. These results add new knowledge on the composition of microbiota and its correlation with barrier permeability and short-chain fatty acids and suggest that more studies are required before these potential biomarkers can be incorporated into the clinical management of patients via immune checkpoint inhibitor treatment.
000133424 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-113963RB-I00$$9info:eu-repo/grantAgreement/ES/DGA/B29-23R
000133424 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000133424 590__ $$a4.4$$b2024
000133424 592__ $$a1.462$$b2024
000133424 591__ $$aONCOLOGY$$b85 / 326 = 0.261$$c2024$$dQ2$$eT1
000133424 593__ $$aOncology$$c2024$$dQ1
000133424 593__ $$aCancer Research$$c2024$$dQ2
000133424 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000133424 700__ $$aZapata-García, María
000133424 700__ $$aGascón-Ruiz, Marta
000133424 700__ $$aSesma, Andrea
000133424 700__ $$aQuílez, Elisa
000133424 700__ $$aRamirez-Labrada, Ariel
000133424 700__ $$0(orcid)0000-0003-3043-147X$$aMartínez-Lostao, Luis$$uUniversidad de Zaragoza
000133424 700__ $$aDomingo, María Pilar
000133424 700__ $$aEsteban, Patricia
000133424 700__ $$aYubero, Alfonso
000133424 700__ $$aBarbero-Herranz, Raquel
000133424 700__ $$aMoreno-Blanco, Ana
000133424 700__ $$0(orcid)0000-0002-9600-8116$$aPaño, José Ramón$$uUniversidad de Zaragoza
000133424 700__ $$aLastra, Rodrigo
000133424 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julián$$uUniversidad de Zaragoza
000133424 700__ $$aIsla, Dolores
000133424 700__ $$adel Campo, Rosa
000133424 700__ $$aGálvez, Eva$$uUniversidad de Zaragoza
000133424 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000133424 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000133424 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000133424 773__ $$g16, 6 (2024), 1144 [15 pp.]$$pCancers$$tCancers$$x2072-6694
000133424 8564_ $$s3880502$$uhttps://zaguan.unizar.es/record/133424/files/texto_completo.pdf$$yVersión publicada
000133424 8564_ $$s2956420$$uhttps://zaguan.unizar.es/record/133424/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000133424 909CO $$ooai:zaguan.unizar.es:133424$$particulos$$pdriver
000133424 951__ $$a2025-09-22-14:43:27
000133424 980__ $$aARTICLE