Resumen: Large machine tools are critically affected by ambient temperature fluctuations, impacting their performance and the quality of machined products. Addressing the challenge of accurately measuring thermal effects on machine structures, this study introduces the Machine Tool Integrated Inverse Multilateration method. This method offers a precise approach for assessing geometric error parameters throughout a machine’s working volume, featuring a low level of uncertainty and high speed suitable for effective temperature change monitoring. A significant innovation is found in the capability to automatically realise the volumetric error characterisation of medium- to large-sized machine tools at intervals of 40–60 min with a measurement uncertainty of 10 µm. This enables the detailed study of thermal errors which are generated due to variations in ambient temperature over extended periods. To validate the method, an extensive experimental campaign was conducted on a ZAYER Arion G™ large machine tool using a LEICA AT960™ laser tracker with four wide-angle retro-reflectors under natural workshop conditions. This research identified two key thermal scenarios, quasi-stationary and changing environments, providing valuable insights into how temperature variations influence machine behaviour. This novel method facilitates the optimization of machine tool operations and the improvement of product quality in industrial environments, marking a significant advancement in manufacturing metrology. Idioma: Inglés DOI: 10.3390/s24072380 Año: 2024 Publicado en: Sensors 24, 7 (2024), 2380 [24 pp.] ISSN: 1424-8220 Financiación: info:eu-repo/grantAgreement/EC/H2020/958357/EU/Interlinked Process, Product and Data Quality framework for Zero-Defects Manufacturing/InterQ Tipo y forma: Artículo (Versión definitiva) Área (Departamento): Área Ing. Procesos Fabricación (Dpto. Ingeniería Diseño Fabri.)