000134590 001__ 134590
000134590 005__ 20240424142035.0
000134590 0247_ $$2doi$$a10.1039/d4cc00462k
000134590 0248_ $$2sideral$$a138274
000134590 037__ $$aART-2024-138274
000134590 041__ $$aeng
000134590 100__ $$aManabe, Yoshiyuki
000134590 245__ $$aSynthesis and immunological evaluation of TLR1/2 ligand-conjugated RBDs as self-adjuvanting vaccine candidates against SARS-CoV-2
000134590 260__ $$c2024
000134590 5060_ $$aAccess copy available to the general public$$fUnrestricted
000134590 5203_ $$aWe synthesized and evaluated Pam3CSK4-conjugated receptor binding domain (RBD)/deglycosylated RBD as potential anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates. Our investigation revealed the critical importance of limiting the number of introduced Pam3CSK4 molecules to the RBD in order to preserve its antigenicity. We also confirmed the harmonious integration of the adjuvant-conjugation strategy with the glycan-shield removal strategy.
000134590 536__ $$9info:eu-repo/grantAgreement/ES/MICINN AEI/PID2022-136362NB-I00
000134590 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000134590 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000134590 700__ $$aGárate-Reyes, Brandon
000134590 700__ $$aIto, Keita
000134590 700__ $$0(orcid)0000-0002-3122-9401$$aHurtado-Guerrero, Ramón
000134590 700__ $$aKabayama, Kazuya
000134590 700__ $$aFukase, Koichi
000134590 773__ $$g60, 29 (2024), 4 pp.$$pChem. commun.$$tChemical Communications$$x1359-7345
000134590 8564_ $$s492286$$uhttps://zaguan.unizar.es/record/134590/files/texto_completo.pdf$$yVersión publicada
000134590 8564_ $$s2794890$$uhttps://zaguan.unizar.es/record/134590/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000134590 909CO $$ooai:zaguan.unizar.es:134590$$particulos$$pdriver
000134590 951__ $$a2024-04-24-13:24:05
000134590 980__ $$aARTICLE