134613 20260217205502.0 doi 10.1021/acs.nanolett.3c04947 sideral 138303 ART-2024-138303 eng Bonet-Aleta, Javier Universidad de Zaragoza (orcid)0000-0002-1791-0188 Nanoparticle-Catalyzed Transamination under Tumor Microenvironment Conditions: A Novel Tool to Disrupt the Pool of Amino Acids and GSSG in Cancer Cells 2024 Access copy available to the general public Unrestricted Catalytic cancer therapy targets cancer cells by exploiting the specific characteristics of the tumor microenvironment (TME). TME-based catalytic strategies rely on the use of molecules already present in the TME. Amino groups seem to be a suitable target, given the abundance of proteins and peptides in biological environments. Here we show that catalytic CuFe2O4 nanoparticles are able to foster transaminations with different amino acids and pyruvate, another key molecule present in the TME. We observed a significant in cellulo decrease in glutamine and alanine levels up to 48 h after treatment. In addition, we found that di- and tripeptides also undergo catalytic transamination, thereby extending the range of the effects to other molecules such as glutathione disulfide (GSSG). Mechanistic calculations for GSSG transamination revealed the formation of an imine between the oxo group of pyruvate and the free −NH2 group of GSSG. Our results highlight transamination as alternative to the existing toolbox of catalytic therapies. info:eu-repo/grantAgreement/ES/DGA/E07-23R info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/grantAgreement/ES/MICINN/IJC-2020-044217-I info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 9.1 2024 CHEMISTRY, PHYSICAL 34 / 185 = 0.184 2024 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 68 / 461 = 0.148 2024 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 24 / 147 = 0.163 2024 Q1 T1 PHYSICS, CONDENSED MATTER 10 / 80 = 0.125 2024 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 34 / 239 = 0.142 2024 Q1 T1 PHYSICS, APPLIED 23 / 187 = 0.123 2024 Q1 T1 2.967 2024 Bioengineering 2024 Q1 Chemistry (miscellaneous) 2024 Q1 Nanoscience and Nanotechnology 2024 Q1 Materials Science (miscellaneous) 2024 Q1 Mechanical Engineering 2024 Q1 Condensed Matter Physics 2024 Q1 14.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alegre-Requena, Juan Vicente (orcid)0000-0002-0769-7168 Martin-Martin, Javier Encinas-Gimenez, Miguel Universidad de Zaragoza Martín-Pardillos, Ana Universidad de Zaragoza Martin-Duque, Pilar Universidad de Zaragoza (orcid)0000-0003-4160-9720 Hueso, Jose L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 Santamaria, Jesus Universidad de Zaragoza (orcid)0000-0002-8701-9745 1013 275 Universidad de Zaragoza Dpto. Cirugía Área Estomatología 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 24, 14 (2024), 4091-4100 Nano lett. Nano Letters 1530-6984 6143885 http://zaguan.unizar.es/record/134613/files/texto_completo.pdf Versión publicada 2889066 http://zaguan.unizar.es/record/134613/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:134613 articulos driver 2026-02-17-20:22:26 ARTICLE