000134641 001__ 134641 000134641 005__ 20240424142036.0 000134641 0247_ $$2doi$$a10.3390/psychoactives3010003 000134641 0248_ $$2sideral$$a138178 000134641 037__ $$aART-2024-138178 000134641 041__ $$aeng 000134641 100__ $$0(orcid)0000-0002-8890-4869$$aFerrer-Pérez, Carmen 000134641 245__ $$aNeurobiological Theories of Addiction: A Comprehensive Review 000134641 260__ $$c2024 000134641 5060_ $$aAccess copy available to the general public$$fUnrestricted 000134641 5203_ $$aIt is essential to develop theories and models that enable us to understand addiction’s genesis and maintenance, providing a theoretical and empirical framework for designing more effective interventions. Numerous clinical and preclinical research studies have investigated the various brain and physiological mechanisms involved in addictive behavior. Some researchers have gone a step further, developing what we may refer to as “neurobiological theories of addiction”, which are scientific models that can explain and predict different addiction phenomena. Many of these neurobiological theories are not mutually exclusive but rather extensions and refinements of earlier theories. They all share a similar definition of addiction as a chronic disease characterized by a loss of control over substance consumption, with the brain being identified as the principal organ involved. Most propose a multifactorial causation in which both biological and environmental factors interact, accentuating or causing neurobiological dysfunction in structures and brain circuits involved in behavior and motivation. This review delves into primary neurobiological theories of addiction, commencing with the opponent-process theory—one of the earliest comprehensive explanations of the addictive process. Subsequently, we explore more contemporary formulations connecting behavioral alterations in the addictive process to changes and disruptions in various brain systems. 000134641 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000134641 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000134641 700__ $$0(orcid)0000-0002-3380-7252$$aMontagud-Romero, Sandra 000134641 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, María Carmen$$uUniversidad de Zaragoza 000134641 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000134641 773__ $$g3, 1 (2024), 13 pp.$$pPsychoactives$$tPsychoactives$$x2813-1851 000134641 8564_ $$s1214788$$uhttps://zaguan.unizar.es/record/134641/files/texto_completo.pdf$$yVersión publicada 000134641 8564_ $$s2734835$$uhttps://zaguan.unizar.es/record/134641/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000134641 909CO $$ooai:zaguan.unizar.es:134641$$particulos$$pdriver 000134641 951__ $$a2024-04-24-13:25:07 000134641 980__ $$aARTICLE