000134841 001__ 134841
000134841 005__ 20240605113631.0
000134841 0247_ $$2doi$$a10.1016/j.medcli.2023.11.032
000134841 0248_ $$2sideral$$a138341
000134841 037__ $$aART-2024-138341
000134841 041__ $$aeng
000134841 100__ $$aGarcía-Mateo, Sandra$$uUniversidad de Zaragoza
000134841 245__ $$aCardiovascular risk assessment in inflammatory bowel disease with metabolic dysfunction-associated steatotic liver disease
000134841 260__ $$c2024
000134841 5203_ $$aBackground and aims: Inflammatory bowel disease (IBD) has been reported to increase the risk of early atherosclerosis even in young patients. Moreover, metabolic dysfunction-associated steatotic liver dis-ease (MASLD), which has been linked to IBD, is a well-recognized but underdiagnosis entity related to cardiovascular risk. We analyze the impact of MASLD in IBD patients’ cardiovascular risk through both advanced lipoprotein profile sorted by nuclear magnetic resonance spectroscopy, and carotid artery intima-media thickness (CIMT).
Methods: Cross-sectional cohort study which involves 941 IBD adult outpatients. Of them, 50 patients with IBD who met criteria for MASLD and 50 with IBD without MASLD, matched by sex and age were included. Alterations in CIMT were evaluated considering abnormal measures above the 75th percentile adjusted for sex and age. Specific advanced lipoprotein profile was also carried out.
Results: Most of the patients had an abnormal CIMT (58%). MASLD (OR = 5.05, CI 95% = 1.71–14.92) and female sex (OR = 3.32, CI 95% = 1.03–10) were significantly associated with CIMT alterations. Dense LDL particles (with high cholesterol composition in general cohort (OR = 3.62, 95% CI = 1.07–12.19) and high triglycerides density in young subgroup (OR = 6.25, 95% CI = 1.04–50) but not total LDL cholesterol were associated with CIMT alterations.
Conclusions: MASLD and female sex are associated with early atherosclerosis in IBD patients. Dense LDL particle in combination with vascular imaging findings should be evaluated as non-invasive tools in the management of cardiovascular risk in IBD patients.
000134841 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000134841 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000134841 700__ $$aMartínez-Domínguez, Samuel J.$$uUniversidad de Zaragoza
000134841 700__ $$0(orcid)0000-0002-3545-2707$$aGargallo-Puyuelo, Carla J.$$uUniversidad de Zaragoza
000134841 700__ $$aGallego, Beatriz
000134841 700__ $$aAlfambra, Erika
000134841 700__ $$0(orcid)0000-0002-9962-6147$$aAso, María C.
000134841 700__ $$aMartinez-Micaelo, Neus
000134841 700__ $$aAmigó, Nuria
000134841 700__ $$aMartínez-García, Javier$$uUniversidad de Zaragoza
000134841 700__ $$aBaptista, Pedro M.
000134841 700__ $$aSanz, Borja
000134841 700__ $$aBallesta, Sara
000134841 700__ $$aEspinosa, Judith
000134841 700__ $$aTejero, Carlos
000134841 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza
000134841 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000134841 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000134841 773__ $$pMed. clín.$$tMedicina clinica$$x0025-7753
000134841 8564_ $$s792951$$uhttps://zaguan.unizar.es/record/134841/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-04-25
000134841 8564_ $$s2166214$$uhttps://zaguan.unizar.es/record/134841/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-04-25
000134841 909CO $$ooai:zaguan.unizar.es:134841$$particulos$$pdriver
000134841 951__ $$a2024-06-05-11:32:21
000134841 980__ $$aARTICLE