000134888 001__ 134888
000134888 005__ 20241125101203.0
000134888 0247_ $$2doi$$a10.1016/j.sjpmh.2023.04.001
000134888 0248_ $$2sideral$$a138331
000134888 037__ $$aART-2023-138331
000134888 041__ $$aeng
000134888 100__ $$aAmoretti, Silvia
000134888 245__ $$aNegative symptoms and sex differences in first episode schizophrenia: What's their role in the functional outcome? A longitudinal study
000134888 260__ $$c2023
000134888 5060_ $$aAccess copy available to the general public$$fUnrestricted
000134888 5203_ $$aIntroduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). The aim of this article was to examine potential sex differences among first-episode schizophrenia (FES) patients and analyze sex-related predictors of two NS symptoms factors (EXP and MAP) and functional outcome. Material and methods: Two hundred and twenty-three FES (71 females and 152 males) were included and evaluated at baseline, six-months and one-year. Repeated measures ANOVA was used to examine the effects of time and sex on NS and a multiple linear regression backward elimination was performed to predict NS factors (MAP-EXP) and functioning. Results: Females showed fewer NS (p = 0.031; Cohen's d = −0.312), especially those related to EXP (p = 0.024; Cohen's d = −0.326) rather than MAP (p = 0.086), than males. In both male and female group, worse premorbid adjustment and higher depressive symptoms made a significant contribution to the presence of higher deficits in EXP at one-year follow-up, while positive and depressive symptoms predicted alterations in MAP. Finally, in females, lower deficits in MAP and better premorbid adjustment predicted better functioning at one-year follow-up (R2 = 0.494; p < 0.001), while only higher deficits in MAP predicted worse functioning in males (R2 = 0.088; p = 0.012). Conclusions: Slightly sex differences have been found in this study. Our results lead us to consider that early interventions of NS, especially those focusing on motivation and pleasure symptoms, could improve functional outcomes.
000134888 536__ $$9info:eu-repo/grantAgreement/EC/H2020/754550/EU/Biomedicine international training research programme for excellent clinician-scientists/BITRECS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 754550-BITRECS$$9info:eu-repo/grantAgreement/ES/ISCIII/CD20-00177$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS-FEDER/PI19-00766$$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-0208$$9info:eu-repo/grantAgreement/ES/MICINN/PI18-00805$$9info:eu-repo/grantAgreement/ES/MICIU/PI21/00787$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO/PI14-00612
000134888 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000134888 590__ $$a0.0$$b2023
000134888 591__ $$aPSYCHIATRY
000134888 591__ $$aPSYCHIATRY
000134888 594__ $$a9.5$$b2023
000134888 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000134888 700__ $$aMezquida, Gisela
000134888 700__ $$aVerdolini, Norma
000134888 700__ $$aBioque, Miquel
000134888 700__ $$aSánchez-Torres, Ana M.
000134888 700__ $$aPina-Camacho, Laura
000134888 700__ $$aZorrilla, Iñaki
000134888 700__ $$aTrabsa, Amira
000134888 700__ $$aRodríguez-Jiménez, Roberto
000134888 700__ $$aCorripio, Iluminada
000134888 700__ $$aSarró, Salvador
000134888 700__ $$aIbáñez, Ángela
000134888 700__ $$aUsall, Judith
000134888 700__ $$aSegarra, Rafael
000134888 700__ $$aVieta, Eduard
000134888 700__ $$aRoberto, Natalia
000134888 700__ $$aRamos-Quiroga, Josep Antoni
000134888 700__ $$aTortorella, Alfonso
000134888 700__ $$aMenculini, Giulia
000134888 700__ $$aCuesta, Manuel J.
000134888 700__ $$aParellada, Mara
000134888 700__ $$aGonzález-Pinto, Ana
000134888 700__ $$aBerrocoso, Esther
000134888 700__ $$aBernardo, Miguel
000134888 700__ $$aForte, María Florencia
000134888 700__ $$aSerra, María
000134888 700__ $$aAlonso-Solís, Anna
000134888 700__ $$aGrasa, Eva
000134888 700__ $$aCorres, Edurne García
000134888 700__ $$aFernández Sevillano, Jessica
000134888 700__ $$aToll, Alba
000134888 700__ $$aMartínez-Sadurní, Laura
000134888 700__ $$aNúñez-Doyle, Aggie
000134888 700__ $$aSánchez-Pastor, Luis
000134888 700__ $$aPomarol-Clotet, Edith
000134888 700__ $$aGuerrero-Pedraza, Amalia
000134888 700__ $$aButjosa, Anna
000134888 700__ $$aPardo, Marta
000134888 700__ $$aLópez-Ilundain, José M.
000134888 700__ $$aRibeiro, María
000134888 700__ $$aSaiz-Ruiz, Jerónimo
000134888 700__ $$aLeón-Quismondo, Leticia
000134888 700__ $$aEscartí, María José
000134888 700__ $$aContreras, Fernando
000134888 700__ $$0(orcid)0000-0003-2284-7862$$aCámara, Concepción de la$$uUniversidad de Zaragoza
000134888 700__ $$aZabala Rabadán, Arantzazu
000134888 700__ $$aPortilla, M. Paz
000134888 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000134888 773__ $$g(2023), [9 pp.]$$pSpan. j. psychiatr. ment. health$$tSpanish journal of psychiatry and mental health$$x2950-2861
000134888 8564_ $$s646665$$uhttps://zaguan.unizar.es/record/134888/files/texto_completo.pdf$$yVersión publicada
000134888 8564_ $$s2799839$$uhttps://zaguan.unizar.es/record/134888/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000134888 909CO $$ooai:zaguan.unizar.es:134888$$particulos$$pdriver
000134888 951__ $$a2024-11-22-12:12:38
000134888 980__ $$aARTICLE