000134953 001__ 134953
000134953 005__ 20240509150148.0
000134953 0247_ $$2doi$$a10.1016/j.envpol.2024.124044
000134953 0248_ $$2sideral$$a138500
000134953 037__ $$aART-2024-138500
000134953 041__ $$aeng
000134953 100__ $$aMérida, Diana María
000134953 245__ $$aPhthalate exposure and subclinical carotid atherosclerosis: A systematic review and meta-analysis
000134953 260__ $$c2024
000134953 5060_ $$aAccess copy available to the general public$$fUnrestricted
000134953 5203_ $$aPhthalates may be associated with an increased risk of cardiometabolic diseases by interfering with glucose and lipid metabolism and by promoting adipogenesis. This study aimed to perform a systematic review and meta-analysis of the association between phthalate exposure and subclinical carotid atherosclerosis, using surrogate markers such as carotid intima-media thickness (IMT) and carotid plaques. The literature search was performed using four databases (Web of Science, Medline, PubMed, and Scopus), and this systematic review includes all available observational studies until July 6th, 2023. The Joanna Briggs Institute critical appraisal tool was used to assess the risk of bias. Meta-analyses were performed, and random effects models were used. Six high-quality cross-sectional studies and 2570 participants aged 12 to 70 were included. Six phthalate metabolites showed significant associations with subclinical carotid atherosclerosis. Exposure to MBzP, ΣDEHP, and MnBP was associated with increased carotid IMT. Exposure to MEP was associated with a higher prevalence of carotid plaques, and MiBP was associated with a lower prevalence. Mixed results were observed for MMP in older adults. The meta-analyses showed a high degree of heterogeneity, and the results are based on single studies. This study accurately describes the evidence of this association to date, suggesting that phthalates are associated with increased carotid IMT and a higher prevalence of carotid plaques. Further research is needed to elucidate this association, as phthalates are still used in the manufacture of everyday products, humans continue to be exposed to them, and atherosclerosis is a public health concern.
000134953 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI20/144
000134953 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000134953 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000134953 700__ $$aAcosta-Reyes, Jorge
000134953 700__ $$aBayán-Bravo, Ana
000134953 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000134953 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000134953 700__ $$aGuallar-Castillón, Pilar
000134953 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000134953 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000134953 773__ $$g350 (2024), 124044 [11 pp.]$$pEnviron. pollut.$$tEnvironmental Pollution$$x0269-7491
000134953 8564_ $$s1521214$$uhttps://zaguan.unizar.es/record/134953/files/texto_completo.pdf$$yVersión publicada
000134953 8564_ $$s2481181$$uhttps://zaguan.unizar.es/record/134953/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000134953 909CO $$ooai:zaguan.unizar.es:134953$$particulos$$pdriver
000134953 951__ $$a2024-05-09-13:05:37
000134953 980__ $$aARTICLE