000135186 001__ 135186
000135186 005__ 20240516095249.0
000135186 0247_ $$2doi$$a10.3390/ijms25084360
000135186 0248_ $$2sideral$$a138545
000135186 037__ $$aART-2024-138545
000135186 041__ $$aeng
000135186 100__ $$aMarco, Alicia
000135186 245__ $$aCurrent Fertility Preservation Steps in Young Women Suffering from Cancer and Future Perspectives
000135186 260__ $$c2024
000135186 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135186 5203_ $$aChildhood cancer incidence, especially in high-income countries, has led to a focus on preserving fertility in this vulnerable population. The common treatments, such as radiation and certain chemotherapeutic agents, though effective, pose a risk to fertility. For adult women, established techniques like embryo and egg freezing are standard, requiring ovarian stimulation. However, for prepubescent girls, ovarian tissue freezing has become the primary option, eliminating the need for hormonal preparation. This review describes the beginning, evolution, and current situation of the fertility preservation options for this young population. A total of 75 studies were included, covering the steps in the current fertility preservation protocols: (i) ovarian tissue extraction, (ii) the freezing method, and (iii) thawing and transplantation. Cryopreservation and the subsequent transplantation of ovarian tissue have resulted in successful fertility restoration, with over 200 recorded live births, including cases involving ovarian tissue cryopreserved from prepubescent girls. Despite promising results, challenges persist, such as follicular loss during transplantation, which is attributed to ischemic and oxidative damage. Optimizing ovarian tissue-freezing processes and exploring alternatives to transplantation, like in vitro systems for follicles to establish maturation, are essential to mitigating associated risks. Further research is required in fertility preservation techniques to enhance clinical outcomes in the future. Ovarian tissue cryopreservation appears to be a method with specific benefits, indications, and risks, which can be an important tool in terms of preserving fertility in younger women.
000135186 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135186 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135186 700__ $$aGargallo, Marta$$uUniversidad de Zaragoza
000135186 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, Jesús$$uUniversidad de Zaragoza
000135186 700__ $$aShikanov, Ariella
000135186 700__ $$aBaquedano, Laura$$uUniversidad de Zaragoza
000135186 700__ $$aGarcía Pérez-Llantada, Javier
000135186 700__ $$aMalo, Clara$$uUniversidad de Zaragoza
000135186 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000135186 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000135186 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000135186 773__ $$g25, 8 (2024), 4360 [16 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000135186 8564_ $$s2202511$$uhttps://zaguan.unizar.es/record/135186/files/texto_completo.pdf$$yVersión publicada
000135186 8564_ $$s2593177$$uhttps://zaguan.unizar.es/record/135186/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135186 909CO $$ooai:zaguan.unizar.es:135186$$particulos$$pdriver
000135186 951__ $$a2024-05-16-08:53:57
000135186 980__ $$aARTICLE