000135308 001__ 135308
000135308 005__ 20241125101152.0
000135308 0247_ $$2doi$$a10.1016/j.jpain.2023.04.005
000135308 0248_ $$2sideral$$a135190
000135308 037__ $$aART-2023-135190
000135308 041__ $$aeng
000135308 100__ $$aFortún-Rabadán, Rocío
000135308 245__ $$aFacilitated Central Pain Mechanisms Across the Menstrual Cycle in Dysmenorrhea and Enlarged Pain Distribution in Women With Longer Pain History
000135308 260__ $$c2023
000135308 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135308 5203_ $$aDysmenorrhea (DYS), or recurrent menstrual pain, is a highly prevalent pain condition among otherwise healthy women. However, the progression of DYS over time and the influence of the menstrual cycle phases need to be better understood. While the location and distribution of pain have been used to assess pain mechanisms in other conditions, they are unexplored in DYS. Thirty otherwise healthy women with severe DYS and 30 healthy control women were recruited into 3 subgroups (n = 10) according to the length of their menstrual history (<5, 5–15, or>15 years since menarche). The intensity and distribution of menstrual pain were recorded. Pressure pain thresholds at abdominal, hip, and arm sites, pressure-induced pain distribution, temporal summation of pain, and pain intensity after pressure cessation over the gluteus medius were assessed at 3 menstrual cycle phases. Compared with the healthy control women, those with DYS showed lower pressure pain thresholds in every site and menstrual cycle phase (P < .05), enlarged pressure-induced pain areas during menstruations (P < .01), and increased temporal summation and pain intensity after pressure cessation in the overall menstrual cycle (P < .05). Additionally, these manifestations were enhanced during the menstrual and premenstrual phases compared to ovulation in women with DYS (P < .01). Women with long-term DYS demonstrated enlarged pressure-induced pain distribution, enlarged menstrual pain areas, and more days with severe menstrual pain compared to the short-term DYS subgroup (P < .01). Pressure-induced and menstrual pain distributions were strongly correlated (P < .001). These findings suggest that severe DYS is a progressive condition underscored by facilitated central pain mechanisms associated with pain recurrence and exacerbation.
000135308 536__ $$9info:eu-repo/grantAgreement/ES/MCIU/FPU19-05237
000135308 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000135308 590__ $$a4.0$$b2023
000135308 592__ $$a1.339$$b2023
000135308 591__ $$aCLINICAL NEUROLOGY$$b51 / 280 = 0.182$$c2023$$dQ1$$eT1
000135308 593__ $$aAnesthesiology and Pain Medicine$$c2023$$dQ1
000135308 591__ $$aNEUROSCIENCES$$b86 / 310 = 0.277$$c2023$$dQ2$$eT1
000135308 593__ $$aNeurology (clinical)$$c2023$$dQ1
000135308 593__ $$aNeurology$$c2023$$dQ1
000135308 594__ $$a6.3$$b2023
000135308 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000135308 700__ $$aBoudreau, Shellie A.
000135308 700__ $$aBellosta-López, Pablo
000135308 700__ $$0(orcid)0000-0002-9201-0120$$aHerrero, Pablo$$uUniversidad de Zaragoza
000135308 700__ $$aGraven-Nielsen, Thomas
000135308 700__ $$aDoménech-García, Víctor
000135308 7102_ $$11006$$2413$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Fisioterapia
000135308 773__ $$g24, 9 (2023), 1541-1554$$pJ. pain$$tJOURNAL OF PAIN$$x1526-5900
000135308 8564_ $$s914753$$uhttps://zaguan.unizar.es/record/135308/files/texto_completo.pdf$$yPostprint
000135308 8564_ $$s1369721$$uhttps://zaguan.unizar.es/record/135308/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000135308 909CO $$ooai:zaguan.unizar.es:135308$$particulos$$pdriver
000135308 951__ $$a2024-11-22-12:07:37
000135308 980__ $$aARTICLE