000135314 001__ 135314
000135314 005__ 20240720100906.0
000135314 0247_ $$2doi$$a10.1002/alz.13846
000135314 0248_ $$2sideral$$a138599
000135314 037__ $$aART-2024-138599
000135314 041__ $$aita
000135314 100__ $$aVan Asbroeck, Stephanie
000135314 245__ $$aLifestyle and incident dementia: A COSMIC individual participant data meta-analysis
000135314 260__ $$c2024
000135314 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135314 5203_ $$aINTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.
000135314 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/DGA/B15-23R$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000135314 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135314 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135314 700__ $$aKöhler, Sebastian
000135314 700__ $$avan Boxtel, Martin P. J.
000135314 700__ $$aLipnicki, Darren M.
000135314 700__ $$aCrawford, John D.
000135314 700__ $$aCastro-Costa, Erico
000135314 700__ $$aLima-Costa, Maria Fernanda
000135314 700__ $$aBlay, Sergio Luis
000135314 700__ $$aShifu, Xiao
000135314 700__ $$aWang, Tao
000135314 700__ $$aYue, Ling
000135314 700__ $$aLipton, Richard B.
000135314 700__ $$aKatz, Mindy J.
000135314 700__ $$aDerby, Carol A.
000135314 700__ $$aGuerchet, Maëlenn
000135314 700__ $$aPreux, Pierre-Marie
000135314 700__ $$aMbelesso, Pascal
000135314 700__ $$aNorton, Joanna
000135314 700__ $$aRitchie, Karen
000135314 700__ $$aSkoog, Ingmar
000135314 700__ $$aNajar, Jenna
000135314 700__ $$aSterner, Therese Rydberg
000135314 700__ $$aScarmeas, Nikolaos
000135314 700__ $$aYannakoulia, Mary
000135314 700__ $$aDardiotis, Themis
000135314 700__ $$aRolandi, Elena
000135314 700__ $$aDavin, Annalisa
000135314 700__ $$aRossi, Michele
000135314 700__ $$aGureje, Oye
000135314 700__ $$aOjagbemi, Akin
000135314 700__ $$aBello, Toyin
000135314 700__ $$aKim, Ki Woong
000135314 700__ $$aHan, Ji Won
000135314 700__ $$aOh, Dae Jong
000135314 700__ $$aTrompet, Stella
000135314 700__ $$aGussekloo, Jacobijn
000135314 700__ $$aRiedel-Heller, Steffi G.
000135314 700__ $$aRöhr, Susanne
000135314 700__ $$aPabst, Alexander
000135314 700__ $$aShahar, Suzana
000135314 700__ $$aRivan, Nurul Fatin Malek
000135314 700__ $$aSingh, Devinder Kaur Ajit
000135314 700__ $$aJacobsen, Erin
000135314 700__ $$aGanguli, Mary
000135314 700__ $$aHughes, Tiffany
000135314 700__ $$aHaan, Mary
000135314 700__ $$aAiello, Allison E.
000135314 700__ $$aDing, Ding
000135314 700__ $$aZhao, Qianhua
000135314 700__ $$aXiao, Zhenxu
000135314 700__ $$aNarazaki, Kenji
000135314 700__ $$aChen, Tao
000135314 700__ $$aChen, Sanmei
000135314 700__ $$aNg, Tze Pin
000135314 700__ $$aGwee, Xinyi
000135314 700__ $$aGao, Qi
000135314 700__ $$aBrodaty, Henry
000135314 700__ $$aTrollor, Julian
000135314 700__ $$aKochan, Nicole
000135314 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000135314 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, Javier$$uUniversidad de Zaragoza
000135314 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-Garcia, Patricia$$uUniversidad de Zaragoza
000135314 700__ $$aSachdev, Perminder S.
000135314 700__ $$aDeckers, Kay
000135314 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000135314 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000135314 773__ $$g20, 6 (2024), 3972-3986$$pAlzheimers & Dementia$$tAlzheimers & Dementia$$x1552-5260
000135314 8564_ $$s1248798$$uhttps://zaguan.unizar.es/record/135314/files/texto_completo.pdf$$yVersión publicada
000135314 8564_ $$s2821043$$uhttps://zaguan.unizar.es/record/135314/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000135314 951__ $$a2024-07-19-18:54:24
000135314 980__ $$aARTICLE