135314 20260217205529.0 doi 10.1002/alz.13846 sideral 138599 ART-2024-138599 ita Van Asbroeck, Stephanie Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis 2024 Access copy available to the general public Unrestricted INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS: We combined data from 21 prospective cohorts across six continents (N = 31,680) and conducted cohort-specific Cox proportional hazard regression analyses in a two-step individual participant data meta-analysis. RESULTS: A one-standard-deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow-up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. info:eu-repo/grantAgreement/ES/DGA/B15-17R info:eu-repo/grantAgreement/ES/DGA/B15-23R info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI16-00896 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 11.1 2024 CLINICAL NEUROLOGY 6 / 286 = 0.021 2024 Q1 T1 3.6 2024 Cellular and Molecular Neuroscience 2024 Q1 Developmental Neuroscience 2024 Q1 Epidemiology 2024 Q1 Psychiatry and Mental Health 2024 Q1 Health Policy 2024 Q1 Neurology (clinical) 2024 Q1 Geriatrics and Gerontology 2024 Q1 13.6 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Köhler, Sebastian van Boxtel, Martin P. J. Lipnicki, Darren M. Crawford, John D. Castro-Costa, Erico Lima-Costa, Maria Fernanda Blay, Sergio Luis Shifu, Xiao Wang, Tao Yue, Ling Lipton, Richard B. Katz, Mindy J. Derby, Carol A. Guerchet, Maëlenn Preux, Pierre-Marie Mbelesso, Pascal Norton, Joanna Ritchie, Karen Skoog, Ingmar Najar, Jenna Sterner, Therese Rydberg Scarmeas, Nikolaos Yannakoulia, Mary Dardiotis, Themis Rolandi, Elena Davin, Annalisa Rossi, Michele Gureje, Oye Ojagbemi, Akin Bello, Toyin Kim, Ki Woong Han, Ji Won Oh, Dae Jong Trompet, Stella Gussekloo, Jacobijn Riedel-Heller, Steffi G. Röhr, Susanne Pabst, Alexander Shahar, Suzana Rivan, Nurul Fatin Malek Singh, Devinder Kaur Ajit Jacobsen, Erin Ganguli, Mary Hughes, Tiffany Haan, Mary Aiello, Allison E. Ding, Ding Zhao, Qianhua Xiao, Zhenxu Narazaki, Kenji Chen, Tao Chen, Sanmei Ng, Tze Pin Gwee, Xinyi Gao, Qi Brodaty, Henry Trollor, Julian Kochan, Nicole Lobo, Antonio Universidad de Zaragoza (orcid)0000-0002-9098-655X Santabárbara, Javier Universidad de Zaragoza (orcid)0000-0002-7297-6104 Gracia-Garcia, Patricia Universidad de Zaragoza (orcid)0000-0001-9822-6312 Sachdev, Perminder S. Deckers, Kay 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 20, 6 (2024), 3972-3986 Alzheimers & Dementia Alzheimers & Dementia 1552-5260 1248798 http://zaguan.unizar.es/record/135314/files/texto_completo.pdf Versión publicada 2821043 http://zaguan.unizar.es/record/135314/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:135314 articulos driver 2026-02-17-20:31:48 ARTICLE