000135316 001__ 135316 000135316 005__ 20240720100906.0 000135316 0247_ $$2doi$$a10.1111/cup.14638 000135316 0248_ $$2sideral$$a138580 000135316 037__ $$aART-2024-138580 000135316 041__ $$aeng 000135316 100__ $$0(orcid)0000-0003-2078-8205$$aGarcía-García, Mar$$uUniversidad de Zaragoza 000135316 245__ $$aGranulomatous dermatitis in the context of chronic myelomonocytic leukemia: More than just reactive infiltrates. An illustrative case report with literature review 000135316 260__ $$c2024 000135316 5060_ $$aAccess copy available to the general public$$fUnrestricted 000135316 5203_ $$aTraditionally, skin involvement in chronic myelomonocytic leukemia (CMML) has been considered to be either specific (leukemia cutis) or non‐specific, with granulomatous dermatitis included in the latter group. More recently, the true nature of the myeloid cells present in the cutaneous infiltrates of this theoretically reactive dermatitis is being clarified with the use of new molecular techniques such as next‐generation sequencing. The same mutations in bone marrow (BM) myeloid neoplastic cells and in the cells of cutaneous infiltrates have been found. We present the case of a 77‐year‐old man who presented with spread and treatment‐resistant skin granulomatous lesions previous to the diagnosis of CMML. The same clonal mutations in SRSF2, IDH1, and RUNX1 were found in both skin and BM with resolution of the lesions after the initiation of azacytidine. In conclusion, we report an exceptional case in which specific granulomatous cutaneous lesions have preceded and allowed the earlier diagnosis of an underlying CMML and a review of all previous similar cases in the literature, including molecular alterations. 000135316 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000135316 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000135316 700__ $$aElbaile, Julia Jiménez 000135316 700__ $$0(orcid)0000-0001-5068-7355$$aAzaceta, Gemma$$uUniversidad de Zaragoza 000135316 700__ $$aLorda, Marta 000135316 700__ $$aPrieto-Torres, Lucía$$uUniversidad de Zaragoza 000135316 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000135316 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología 000135316 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica 000135316 773__ $$g51, 8 (2024), 752-760$$pJ. cutan. pathol.$$tJOURNAL OF CUTANEOUS PATHOLOGY$$x0303-6987 000135316 8564_ $$s154550$$uhttps://zaguan.unizar.es/record/135316/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-05-16 000135316 8564_ $$s854976$$uhttps://zaguan.unizar.es/record/135316/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-05-16 000135316 909CO $$ooai:zaguan.unizar.es:135316$$particulos$$pdriver 000135316 951__ $$a2024-07-19-18:54:25 000135316 980__ $$aARTICLE