135316 20260218073401.0 doi 10.1111/cup.14638 sideral 138580 ART-2024-138580 eng (orcid)0000-0003-2078-8205 García-García, Mar Universidad de Zaragoza Granulomatous dermatitis in the context of chronic myelomonocytic leukemia: More than just reactive infiltrates. An illustrative case report with literature review 2024 Access copy available to the general public Unrestricted Traditionally, skin involvement in chronic myelomonocytic leukemia (CMML) has been considered to be either specific (leukemia cutis) or non‐specific, with granulomatous dermatitis included in the latter group. More recently, the true nature of the myeloid cells present in the cutaneous infiltrates of this theoretically reactive dermatitis is being clarified with the use of new molecular techniques such as next‐generation sequencing. The same mutations in bone marrow (BM) myeloid neoplastic cells and in the cells of cutaneous infiltrates have been found. We present the case of a 77‐year‐old man who presented with spread and treatment‐resistant skin granulomatous lesions previous to the diagnosis of CMML. The same clonal mutations in SRSF2, IDH1, and RUNX1 were found in both skin and BM with resolution of the lesions after the initiation of azacytidine. In conclusion, we report an exceptional case in which specific granulomatous cutaneous lesions have preceded and allowed the earlier diagnosis of an underlying CMML and a review of all previous similar cases in the literature, including molecular alterations. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 1.1 2024 PATHOLOGY 66 / 90 = 0.733 2024 Q3 T3 DERMATOLOGY 74 / 96 = 0.771 2024 Q4 T3 0.564 2024 Dermatology 2024 Q2 Pathology and Forensic Medicine 2024 Q2 Histology 2024 Q2 3.2 2024 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Elbaile, Julia Jiménez (orcid)0000-0001-5068-7355 Azaceta, Gemma Universidad de Zaragoza Lorda, Marta Prieto-Torres, Lucía Universidad de Zaragoza 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 1013 020 Universidad de Zaragoza Dpto. Cirugía Área Anatomía Patológica 51, 8 (2024), 752-760 J. cutan. pathol. JOURNAL OF CUTANEOUS PATHOLOGY 0303-6987 154550 http://zaguan.unizar.es/record/135316/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2025-05-16 854976 http://zaguan.unizar.es/record/135316/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2025-05-16 oai:zaguan.unizar.es:135316 articulos driver 2026-02-17-20:32:48 ARTICLE