000135343 001__ 135343
000135343 005__ 20240522124406.0
000135343 0247_ $$2doi$$a10.1080/01652176.2024.2349674
000135343 0248_ $$2sideral$$a138619
000135343 037__ $$aART-2024-138619
000135343 041__ $$aeng
000135343 100__ $$aSola Fraca, Diego$$uUniversidad de Zaragoza
000135343 245__ $$aSleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography
000135343 260__ $$c2024
000135343 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135343 5203_ $$aNeurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopathies (TSEs). Sleep and circadian rhythm disturbances are one of the most common symptoms in patients with neurodegenerative diseases. Currently, one of the main objectives in the study of TSEs is to try to establish an early diagnosis, as clinical signs do not appear until the damage to the central nervous system is very advanced, which prevents any therapeutic approach. In this paper, we provide the first description of sleep disturbance caused by classical scrapie in clinical and preclinical sheep using polysomnography compared to healthy controls. Fifteen sheep classified into three groups, clinical, preclinical and negative control, were analysed. The results show a decrease in total sleep time as the disease progresses, with significant changes between control, clinical and pre-clinical animals. The results also show an increase in sleep fragmentation in clinical animals compared to preclinical and control animals. In addition, sheep with clinical scrapie show a total loss of Rapid Eye Movement sleep (REM) and alterations in Non Rapid Eyes Movement sleep (NREM) compared to control sheep, demonstrating more shallow sleep. Although further research is needed, these results suggest that prion diseases also produce sleep disturbances in animals and that polysomnography could be a diagnostic tool of interest in clinical and preclinical cases of prion diseases.
000135343 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A19-20R
000135343 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000135343 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135343 700__ $$aSánchez Garrigós, Ernesto
000135343 700__ $$aFrancisco Moure, Jorge de
000135343 700__ $$0(orcid)0000-0002-1590-3347$$aMarín González, Belén$$uUniversidad de Zaragoza
000135343 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola Díez, Juan José$$uUniversidad de Zaragoza
000135343 700__ $$0(orcid)0000-0001-5105-6133$$aAcín Tresaco, Cristina$$uUniversidad de Zaragoza
000135343 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000135343 773__ $$g44, 1 (2024), 1-9$$pVet. q.$$tVETERINARY QUARTERLY$$x0165-2176
000135343 8564_ $$s3002446$$uhttps://zaguan.unizar.es/record/135343/files/texto_completo.pdf$$yVersión publicada
000135343 8564_ $$s3057036$$uhttps://zaguan.unizar.es/record/135343/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135343 909CO $$ooai:zaguan.unizar.es:135343$$particulos$$pdriver
000135343 951__ $$a2024-05-22-10:17:33
000135343 980__ $$aARTICLE