135343 20260217205555.0 doi 10.1080/01652176.2024.2349674 sideral 138619 ART-2024-138619 eng Sola Fraca, Diego Universidad de Zaragoza Sleep disturbance in clinical and preclinical scrapie-infected sheep measured by polysomnography 2024 Access copy available to the general public Unrestricted Neurodegenerative diseases are characterised by neuronal loss and abnormal deposition of pathological proteins in the nervous system. Among the most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease and transmissible spongiform encephalopathies (TSEs). Sleep and circadian rhythm disturbances are one of the most common symptoms in patients with neurodegenerative diseases. Currently, one of the main objectives in the study of TSEs is to try to establish an early diagnosis, as clinical signs do not appear until the damage to the central nervous system is very advanced, which prevents any therapeutic approach. In this paper, we provide the first description of sleep disturbance caused by classical scrapie in clinical and preclinical sheep using polysomnography compared to healthy controls. Fifteen sheep classified into three groups, clinical, preclinical and negative control, were analysed. The results show a decrease in total sleep time as the disease progresses, with significant changes between control, clinical and pre-clinical animals. The results also show an increase in sleep fragmentation in clinical animals compared to preclinical and control animals. In addition, sheep with clinical scrapie show a total loss of Rapid Eye Movement sleep (REM) and alterations in Non Rapid Eyes Movement sleep (NREM) compared to control sheep, demonstrating more shallow sleep. Although further research is needed, these results suggest that prion diseases also produce sleep disturbances in animals and that polysomnography could be a diagnostic tool of interest in clinical and preclinical cases of prion diseases. info:eu-repo/grantAgreement/ES/DGA/A19-20R info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 5.2 2024 VETERINARY SCIENCES 5 / 170 = 0.029 2024 Q1 T1 1.308 2024 Veterinary (miscellaneous) 2024 Q1 Medicine (miscellaneous) 2024 Q1 7.8 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sánchez Garrigós, Ernesto Francisco Moure, Jorge de Marín González, Belén Universidad de Zaragoza (orcid)0000-0002-1590-3347 Badiola Díez, Juan José Universidad de Zaragoza (orcid)0000-0002-7173-7216 Acín Tresaco, Cristina Universidad de Zaragoza (orcid)0000-0001-5105-6133 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 44, 1 (2024), 1-9 Vet. q. VETERINARY QUARTERLY 0165-2176 3002446 http://zaguan.unizar.es/record/135343/files/texto_completo.pdf Versión publicada 3057036 http://zaguan.unizar.es/record/135343/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:135343 articulos driver 2026-02-17-20:42:24 ARTICLE