000135348 001__ 135348
000135348 005__ 20240829112948.0
000135348 0247_ $$2doi$$a10.1007/s11259-024-10370-8
000135348 0248_ $$2sideral$$a138614
000135348 037__ $$aART-2024-138614
000135348 041__ $$aeng
000135348 100__ $$aCalvo-Sánchez, Natalia
000135348 245__ $$aA case report of acute claudication due to vena cava thromboembolism in a dog naturally infected with Leishmania Infantum
000135348 260__ $$c2024
000135348 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135348 5203_ $$aCanine leishmaniosis is a vector-borne disease caused by Leishmania infantum, and clinical manifestations of infection range from absent or severe to fatal and result from immune-mediated mechanisms. In dogs, the most common clinical signs of leishmaniosis include skin lesions and lymphadenomegaly. However, the presence of other nontypical signs has been described, and diagnosing these cases can be challenging. The aim of the present short communication was to describe the impact of the formation of circulating immunocomplexes due to L. infantum in a dog with leishmaniosis affected by a massive venous thrombus of the caudal vena cava and external iliac veins. On admission, the dog presented bilateral cutaneous vasculopathy of the thigh and renal disease due to L. infantum infection. Two weeks after starting anti-Leishmania treatment based on meglumine antimoniate and allopurinol administration, the animal developed acute claudication of the hind limbs with the presence of a thrombus in the caudal vena cava and the external iliac veins and a high level of circulating immunocomplexes detected by enzyme-linked immunosorbent assay. Exacerbation of the humoral immune response, along with deposition of circulating immune complexes in the tissues and the concurrent presence of kidney and liver damage, might have contributed to an imbalance in haemostasis in this patient. Future studies should evaluate and analyse the pathological mechanisms contributing to thrombosis in dogs with leishmaniosis.
000135348 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135348 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135348 700__ $$aGómez, Álex$$uUniversidad de Zaragoza
000135348 700__ $$aPérez, Estela$$uUniversidad de Zaragoza
000135348 700__ $$0(orcid)0000-0003-4417-7919$$aBorobia, María
000135348 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000135348 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza
000135348 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000135348 700__ $$0(orcid)0000-0003-2957-1379$$aVerde, Maite$$uUniversidad de Zaragoza
000135348 700__ $$aMarteles, Diana$$uUniversidad de Zaragoza
000135348 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000135348 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000135348 773__ $$g48 (2024), 2663–2669$$pVet. res. commun.$$tVeterinary Research Communications$$x0165-7380
000135348 8564_ $$s9509272$$uhttps://zaguan.unizar.es/record/135348/files/texto_completo.pdf$$yVersión publicada
000135348 8564_ $$s2151544$$uhttps://zaguan.unizar.es/record/135348/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135348 909CO $$ooai:zaguan.unizar.es:135348$$particulos$$pdriver
000135348 951__ $$a2024-08-29-11:26:09
000135348 980__ $$aARTICLE