000135370 001__ 135370
000135370 005__ 20240524100200.0
000135370 037__ $$aTESIS-2024-166
000135370 041__ $$aeng
000135370 1001_ $$aBayona Ramón Y Cajal, Rocío
000135370 24500 $$aITGαVβ3 targeting scFvs as inhibitors of intercellular communication and breast cancer metastasis
000135370 260__ $$aZaragoza$$bUniversidad de Zaragoza, Prensas de la Universidad$$c2023
000135370 300__ $$a104
000135370 4900_ $$aTesis de la Universidad de Zaragoza$$v2024-158$$x2254-7606
000135370 500__ $$aPresentado: 18 12 2023
000135370 502__ $$aTesis-Univ. Zaragoza, , 2023$$bZaragoza, Universidad de Zaragoza$$c2023
000135370 506__ $$aby-nc$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc/3.0/es
000135370 520__ $$aIn recent years, significant progress has been made in breast cancer treatment. However, metastatic breast cancer continues to have a bleak prognosis, with 5-year survival rates dropping below 20%.<br />Studies on tumor stress resistance have unveiled various crucial molecular elements. Notably, the uptake of extracellular vesicles (EV) has emerged as a critical factor in intracellular communication and advancing breast cancer metastasis. Moreover, the role of integrins, a class of cell surface receptors, in facilitating EV uptake and promoting cancer progression has gathered a significant amount of attention during these years of research.<br />The ITG Vß3 dimer has been identified as a pivotal molecular entity involved in the uptake of EVs by breast cancer cells through endocytosis. This finding has streamlined in vitro and in vivo screening for specific inhibitors capable of delaying or preventing the progression of breast cancer metastasis. A high-throughput system has been refined to enable real-time monitoring of drugs that can inhibit EV uptake.<br />In this project, a targeted single-chain variable fragment (scFv) has been successfully generated among the molecules disrupting the metastasis-promoting process. Preliminary trials with this scFv have shown promising outcomes, suggesting its potential to impede EV internalization and decrease metastatic dissemination. This inhibitor exhibits promising capabilities to intervene in the metastatic pathway.<br />
000135370 520__ $$a<br />
000135370 521__ $$97073$$aPrograma de Doctorado en Bioquímica y Biología Molecular
000135370 540__ $$9info:eu-repo/semantics/embargoedAccess
000135370 691__ $$a0
000135370 692__ $$a
000135370 700__ $$aRamón y Cajal Agueras, Santiago José $$edir.
000135370 700__ $$aJiménez Schuhmacher, Alberto $$edir.
000135370 7102_ $$aUniversidad de Zaragoza$$b
000135370 830__ $$9485
000135370 8560_ $$fcdeurop@unizar.es
000135370 8564_ $$s3818364$$uhttps://zaguan.unizar.es/record/135370/files/TESIS-2024-166.pdf$$zinfo:eu-repo/date/embargoEnd/2025-12-17
000135370 909CO $$ooai:zaguan.unizar.es:135370$$pdriver
000135370 909co $$ptesis
000135370 9102_ $$aCiencias$$b
000135370 980__ $$aTESIS