000135584 001__ 135584
000135584 005__ 20240605121015.0
000135584 0247_ $$2doi$$a10.1038/s41584-024-01109-5
000135584 0248_ $$2sideral$$a138713
000135584 037__ $$aART-2024-138713
000135584 041__ $$aeng
000135584 100__ $$aAubert, Alexandre
000135584 245__ $$aGranzyme serine proteases in inflammation and rheumatic diseases
000135584 260__ $$c2024
000135584 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135584 5203_ $$aGranzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes since their discovery more than 30 years ago. Predominantly produced by cytotoxic lymphocytes and natural killer cells, granzymes are delivered into the cytoplasm of target cells through immunological synapses in cooperation with the pore-forming protein perforin. After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also demonstrates the existence of non-cytotoxic, pro-inflammatory, intracellular and extracellular functions that are granzyme specific. Under pathological conditions, granzymes can be produced and secreted extracellularly by immune cells as well as by non-immune cells. Depending on the granzyme, accumulation in the extracellular milieu might contribute to inflammation, tissue injury, impaired wound healing, barrier dysfunction, osteoclastogenesis and/or autoantigen generation.
000135584 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000135584 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135584 700__ $$aJung, Karen
000135584 700__ $$aHiroyasu, Sho
000135584 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, Julian$$uUniversidad de Zaragoza
000135584 700__ $$aGranville, David J.
000135584 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000135584 773__ $$g20, 6 (2024), 361-376$$pNature Reviews Rheumatology$$tNature Reviews Rheumatology$$x1759-4790
000135584 8564_ $$s2674645$$uhttps://zaguan.unizar.es/record/135584/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/semantics/openAccess
000135584 8564_ $$s1926954$$uhttps://zaguan.unizar.es/record/135584/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/semantics/openAccess
000135584 909CO $$ooai:zaguan.unizar.es:135584$$particulos$$pdriver
000135584 951__ $$a2024-06-05-10:51:00
000135584 980__ $$aARTICLE