135584 20260218073454.0 doi 10.1038/s41584-024-01109-5 sideral 138713 ART-2024-138713 eng Aubert, Alexandre Granzyme serine proteases in inflammation and rheumatic diseases 2024 Access copy available to the general public Unrestricted Granzymes (granule-secreted enzymes) are a family of serine proteases that have been viewed as redundant cytotoxic enzymes since their discovery more than 30 years ago. Predominantly produced by cytotoxic lymphocytes and natural killer cells, granzymes are delivered into the cytoplasm of target cells through immunological synapses in cooperation with the pore-forming protein perforin. After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also demonstrates the existence of non-cytotoxic, pro-inflammatory, intracellular and extracellular functions that are granzyme specific. Under pathological conditions, granzymes can be produced and secreted extracellularly by immune cells as well as by non-immune cells. Depending on the granzyme, accumulation in the extracellular milieu might contribute to inflammation, tissue injury, impaired wound healing, barrier dysfunction, osteoclastogenesis and/or autoantigen generation. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 32.7 2024 RHEUMATOLOGY 1 / 58 = 0.017 2024 Q1 T1 5.507 2024 Rheumatology 2024 Q1 31.3 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jung, Karen Hiroyasu, Sho (orcid)0000-0003-0154-0730 Pardo, Julian Universidad de Zaragoza Granville, David J. 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 20, 6 (2024), 361-376 Nature Reviews Rheumatology Nature Reviews Rheumatology 1759-4790 2674645 http://zaguan.unizar.es/record/135584/files/texto_completo.pdf Versión publicada info:eu-repo/date/embargoEnd/2024-12-02 1926954 http://zaguan.unizar.es/record/135584/files/texto_completo.jpg?subformat=icon icon Versión publicada info:eu-repo/date/embargoEnd/2024-12-02 oai:zaguan.unizar.es:135584 articulos driver 2026-02-17-20:35:12 ARTICLE