135592 20260217205559.0 doi 10.1167/tvst.13.5.11 sideral 138707 ART-2024-138707 eng Fantaci, Benedetta Universidad de Zaragoza Establishing standardization guidelines for finite-element optomechanical simulations of refractive laser surgeries: An application to photorefractive keratectomy 2024 Access copy available to the general public Unrestricted Purpose: Computational models can help clinicians plan surgeries by accounting for factors such as mechanical imbalances or testing different surgical techniques beforehand. Different levels of modeling complexity are found in the literature, and it is still not clear what aspects should be included to obtain accurate results in finite-element (FE) corneal models. This work presents a methodology to narrow down minimal requirements of modeling features to report clinical data for a refractive intervention such as PRK. Methods: A pipeline to create FE models of a refractive surgery is presented: It tests different geometries, boundary conditions, loading, and mesh size on the optomechanical simulation output. The mechanical model for the corneal tissue accounts for the collagen fiber distribution in human corneas. Both mechanical and optical outcome are analyzed for the different models. Finally, the methodology is applied to five patient-specific models to ensure accuracy. Results: To simulate the postsurgical corneal optomechanics, our results suggest that the most precise outcome is obtained with patient-specific models with a 100 µm mesh size, sliding boundary condition at the limbus, and intraocular pressure enforced as a distributed load. Conclusions: A methodology for laser surgery simulation has been developed that is able to reproduce the optical target of the laser intervention while also analyzing the mechanical outcome. Translational Relevance: The lack of standardization in modeling refractive interventions leads to different simulation strategies, making difficult to compare them against other publications. This work establishes the standardization guidelines to be followed when performing optomechanical simulations of refractive interventions. info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/EC/H2020/956720/EU/Opto-Biomechanical Eye Research Network/OBERON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 956720-OBERON info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.6 2024 OPHTHALMOLOGY 26 / 99 = 0.263 2024 Q2 T1 0.992 2024 Ophthalmology 2024 Q1 Biomedical Engineering 2024 Q1 4.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Calvo, Begoña Universidad de Zaragoza (orcid)0000-0001-9713-1813 Barraquer, Rafael Picó, Andrés Ariza-Gracia, Miguel Ángel (orcid)0000-0002-6773-6667 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 13, 5 (2024), 11[19 pp.] Transl. vis. sci. technol. Translational Vision Science and Technology 2164-2591 5130015 http://zaguan.unizar.es/record/135592/files/texto_completo.pdf Versión publicada 2670655 http://zaguan.unizar.es/record/135592/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:135592 articulos driver 2026-02-17-20:43:52 ARTICLE