135603 20260217205602.0 doi 10.1093/rheumatology/keae197 sideral 138689 ART-2024-138689 eng Gracia Tello, Borja del Carmelo Universidad de Zaragoza (orcid)0000-0003-3248-2908 Capi-score: a quantitative algorithm for identifying disease patterns in nailfold videocapillaroscopy 2024 Access copy available to the general public Unrestricted Objectives EULAR supports the use of nailfold videocapillaroscopy (NVC) for identifying disease patterns (DPs) associated with SSc and RP. Recently, EULAR proposed an easy-to-manage procedure, a so-called Fast Track algorithm, for differentiating SSc patterns from non-SSc patterns in NVC specimens. However, subjectivity among capillaroscopists remains a limitation. Our aim was to perform a software-based analysis of NVC peculiarities in a cohort of samples from SSc and RP patients and, subsequently, build a Fast Track–inspired algorithm for identifying DPs without the constraint of interobserver variability. Methods NVCs were examined by 9 capillaroscopists. Those NVCs whose DPs were consensually agreed upon (by ≥2 out of 3 interobservers) were subsequently analysed using in-house–developed software. The results for each variable were grouped according to the consensually agreed-upon DPs in order to identify useful hallmarks for categorizing them. Results A total of 851 NVCs (21 957 images) whose DPs had been consensually agreed upon were software-analysed. Appropriate cut-offs set for capillary density and percentage of abnormal and giant capillaries, tortuosities and haemorrhages allowed DP categorization and the development of the CAPI-score algorithm. This consisted of four rules: Rule 1, SSc vs non-SSc, accuracy 0.88; Rules 2 and 3, SSc-early vs SSc-active vs SSc-late, accuracy 0.82; Rule 4, non-SSc normal vs non-SSc non-specific, accuracy 0.73. Accuracy improved when the analysis was limited to NVCs whose DPs had achieved full consensus between the interobservers. Conclusion The CAPI-score algorithm may become a tool that is useful in assigning DPs by overcoming the limitations of subjectivity. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.4 2024 RHEUMATOLOGY 9 / 58 = 0.155 2024 Q1 T1 1.721 2024 Rheumatology 2024 Q1 Pharmacology (medical) 2024 Q1 9.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sáez Comet, Luis Universidad de Zaragoza (orcid)0000-0002-9868-6498 Lledó, Gema Freire Dapena, Mayka Mesa, Miguel Antonio Martín-Cascón, Miguel Guillén del Castillo, Alfredo Martínez Robles, Elena Simeón-Aznar, Carmen Pilar Todolí Parra, Jose Antonio Varela, Diana Cristina Maldonado Vélez, Genessis Marín Ballvé, Adela Universidad de Zaragoza (orcid)0000-0002-7815-8356 Aramburu Llorente, Jimena Pérez Abad, Laura Ramos Ibáñez, Eduardo 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 63, 12 (2024), 3315–3321 Rheumatology (Oxford) Rheumatology (Oxford) 1462-0324 526183 http://zaguan.unizar.es/record/135603/files/texto_completo.pdf Versión publicada 2703534 http://zaguan.unizar.es/record/135603/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:135603 articulos driver 2026-02-17-20:45:25 ARTICLE