000135737 001__ 135737
000135737 005__ 20241125101203.0
000135737 0247_ $$2doi$$a10.1017/S0033291723003185
000135737 0248_ $$2sideral$$a138769
000135737 037__ $$aART-2023-138769
000135737 041__ $$aeng
000135737 100__ $$aCostas-Carrera, Ana
000135737 245__ $$aDifficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis
000135737 260__ $$c2023
000135737 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135737 5203_ $$aPatients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances.
Methods
We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis–Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups.
Results
FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio.
Conclusions
Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture.
000135737 536__ $$9info:eu-repo/grantAgreement/ES/FEDER CB07-09-0023$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI15-00723$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI18-00753$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI21-0070$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2017-23144$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/PI11-00325$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII-FEDER/PI14-00612$$9info:eu-repo/grantAgreement/ES/MINECO/PI08-0208
000135737 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000135737 590__ $$a5.9$$b2023
000135737 592__ $$a2.768$$b2023
000135737 591__ $$aPSYCHIATRY$$b23 / 279 = 0.082$$c2023$$dQ1$$eT1
000135737 593__ $$aPsychiatry and Mental Health$$c2023$$dQ1
000135737 591__ $$aPSYCHOLOGY, CLINICAL$$b6 / 180 = 0.033$$c2023$$dQ1$$eT1
000135737 593__ $$aApplied Psychology$$c2023$$dQ1
000135737 591__ $$aPSYCHIATRY$$b23 / 279 = 0.082$$c2023$$dQ1$$eT1
000135737 591__ $$aPSYCHOLOGY$$b7 / 92 = 0.076$$c2023$$dQ1$$eT1
000135737 594__ $$a11.3$$b2023
000135737 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135737 700__ $$aVerdolini, Norma
000135737 700__ $$aGarcia-Rizo, Clemente
000135737 700__ $$aMezquida, Gisela
000135737 700__ $$aJanssen, Joost
000135737 700__ $$aValli, Isabel
000135737 700__ $$aCorripio, Iluminada
000135737 700__ $$aSanchez-Torres, Ana M.
000135737 700__ $$aBioque, Miquel
000135737 700__ $$0(orcid)0000-0003-3025-8048$$aLobo, Antonio$$uUniversidad de Zaragoza
000135737 700__ $$aGonzalez-Pinto, Ana
000135737 700__ $$aRapado-Castro, Marta
000135737 700__ $$aVieta, Eduard
000135737 700__ $$aDe la Serna, Helena
000135737 700__ $$aMane, Anna
000135737 700__ $$aRoldan, Alexandra
000135737 700__ $$aCrossley, Nicolas
000135737 700__ $$aPenades, Rafael
000135737 700__ $$aCuesta, Manuel J.
000135737 700__ $$aParellada, Mara
000135737 700__ $$aBernardo, Miquel
000135737 700__ $$a
000135737 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000135737 773__ $$g54, 7 (2023), 1339-1349$$pPsychol. med.$$tPsychological Medicine$$x0033-2917
000135737 8564_ $$s306079$$uhttps://zaguan.unizar.es/record/135737/files/texto_completo.pdf$$yVersión publicada
000135737 8564_ $$s3138521$$uhttps://zaguan.unizar.es/record/135737/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135737 909CO $$ooai:zaguan.unizar.es:135737$$particulos$$pdriver
000135737 951__ $$a2024-11-22-12:12:47
000135737 980__ $$aARTICLE