000135775 001__ 135775
000135775 005__ 20240614091948.0
000135775 0247_ $$2doi$$a10.1016/j.molliq.2024.125069
000135775 0248_ $$2sideral$$a138778
000135775 037__ $$aART-2024-138778
000135775 041__ $$aeng
000135775 100__ $$aPadilla, Nuria
000135775 245__ $$aCharacterization of camphor: thymol or dl-menthol eutectic mixtures; Structure, thermophysical properties, and lidocaine solubility
000135775 260__ $$c2024
000135775 5060_ $$aAccess copy available to the general public$$fUnrestricted
000135775 5203_ $$aThe low solubility of drugs in aqueous media is a major problem for the pharmaceutical industry. Among the solutions proposed, the use of eutectic mixtures can be highlighted. In them, the components used can also increase the therapeutic advantages of the active principle. In this work, we analyzed the solubility of lidocaine in mixtures of camphor + thymol or dl-menthol. These binary eutectic solvents were also characterized. For all this, several NMR techniques were used and different thermophysical properties (density, speed of sound, refraction index, isobaric molar heat capacity, surface tension, and kinematic viscosity) were measured. The results indicated that the interaction of camphor with thymol was stronger than with dl-menthol, providing a more compact fluid. On the contrary, the steric hindrance was greater in the mixture with dl-menthol, giving rise to a more viscous liquid. Furthermore, the lidocaine was significantly more soluble (up to 540 times) in these mixtures than in water. The lidocaine showed the strongest interactions with thymol molecules, somewhat weaker with dl-menthol, and the weakest were with camphor ones.
000135775 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E31-23R
000135775 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000135775 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000135775 700__ $$aDelso, Ignacio
000135775 700__ $$0(orcid)0000-0003-3641-1568$$aBergua, Fernando$$uUniversidad de Zaragoza
000135775 700__ $$0(orcid)0000-0003-3632-6822$$aLafuente, Carlos$$uUniversidad de Zaragoza
000135775 700__ $$0(orcid)0000-0003-1810-9488$$aArtal, Manuela$$uUniversidad de Zaragoza
000135775 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000135775 773__ $$g405 (2024), 125069 [13 pp.]$$pJ. mol. liq.$$tJournal of Molecular Liquids$$x0167-7322
000135775 8564_ $$s1639979$$uhttps://zaguan.unizar.es/record/135775/files/texto_completo.pdf$$yVersión publicada
000135775 8564_ $$s2566799$$uhttps://zaguan.unizar.es/record/135775/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000135775 909CO $$ooai:zaguan.unizar.es:135775$$particulos$$pdriver
000135775 951__ $$a2024-06-14-09:00:07
000135775 980__ $$aARTICLE