000135783 001__ 135783 000135783 005__ 20240614091948.0 000135783 0247_ $$2doi$$a10.1016/j.rvsc.2024.105309 000135783 0248_ $$2sideral$$a138812 000135783 037__ $$aART-2024-138812 000135783 041__ $$aeng 000135783 100__ $$aLarrán, Belén 000135783 245__ $$aTrace element status in canine endocrine diseases 000135783 260__ $$c2024 000135783 5060_ $$aAccess copy available to the general public$$fUnrestricted 000135783 5203_ $$aA balanced trace element status is essential for the optimal functioning of all organisms. However, their concentrations are often altered in diverse medical conditions. This study investigated the trace element profiles in plasma samples of dogs with endocrine diseases and used chemometric techniques to explore their associations with biochemical data. Thirteen elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se and Zn) were measured in 40 dogs with hyperadrenocorticism (HAC), 29 dogs with diabetes mellitus (DM), 11 dogs with hypothyroidism (HT) and 30 control dogs using inductively coupled plasma mass spectrometry (ICP-MS). Statistically significant differences were observed for As, Cu, Mo, Se and Zn. In comparison with the control group, the HT patients had higher As and lower Se levels, while the HAC group had higher concentrations of Mo. All three disease groups had higher Cu and Zn concentrations than the control group, with the DM group having higher Cu concentrations and the HAC group higher Zn concentrations than the other endocrinopathy groups. The chemometric analysis revealed distinctive association patterns for discriminating each pathology group and the control group. Moreover, the analysis revealed the following associations: Mo with glucose levels and Cu with fructosamine levels in the DM group, As with cortisol levels in the HAC group, and Se with TT4 levels and As with TSH levels in the HT group. The study findings provide valuable insights into the complex relationships between trace elements and endocrinopathies, elucidating the associations with biochemical markers in these diseases. Larger-scale studies are necessary to fully understand the observed relationships and explore the potential clinical applications. 000135783 536__ $$9info:eu-repo/grantAgreement/ES/MCIU/FPU21/01742 000135783 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000135783 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000135783 700__ $$0(orcid)0000-0002-1934-5397$$aLoste, Araceli$$uUniversidad de Zaragoza 000135783 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza 000135783 700__ $$aMiranda, Marta 000135783 700__ $$aLópez-Alonso, Marta 000135783 700__ $$aHerrero-Latorre, Carlos 000135783 700__ $$0(orcid)0000-0003-0926-9586$$aMarca, M. Carmen 000135783 700__ $$aOrjales, Inmaculada 000135783 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000135783 773__ $$g174 (2024), 105309 [9 pp.]$$pRes. Vet. Sci.$$tRESEARCH IN VETERINARY SCIENCE$$x0034-5288 000135783 8564_ $$s2582883$$uhttps://zaguan.unizar.es/record/135783/files/texto_completo.pdf$$yVersión publicada 000135783 8564_ $$s2529684$$uhttps://zaguan.unizar.es/record/135783/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000135783 909CO $$ooai:zaguan.unizar.es:135783$$particulos$$pdriver 000135783 951__ $$a2024-06-14-09:00:19 000135783 980__ $$aARTICLE